110 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics

    Stanley Nithianantham et al.
    Soluble αβ-tubulin assembly is regulated by a cage-like molecular complex containing tubulin cofactors and Arl2.
    1. Neuroscience

    Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse

    Erica Tagliatti et al.
    The small GTPase Arf6 plays a role in setting the size of the readily releasable pool of synaptic vesicles and in the definition of the recycling route for endocytosed vesicles.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins

    Katja Gotthardt et al.
    The ciliary G-protein Arl13B – which is often mutated in Joubert syndrome – is the Guanine nucleotide exchange factor for the G-protein Arl3 and exclusively localizes to cilia.
    1. Structural Biology and Molecular Biophysics

    Intraflagellar Transport: Moving proteins along in the cilium

    Narcis Adrian Petriman, Esben Lorentzen
    The structures of the bovine and human BBSome reveal that a conformational change is required to recruit the complex to the ciliary membrane.
    Insight
    Available as:
    • HTML
    • PDF
    1. Structural Biology and Molecular Biophysics

    Structure of the human BBSome core complex

    Björn Udo Klink et al.
    The structure of the human BBSome explains how the subunits interact with each other and how disease-causing mutations hamper this interaction.
    1. Structural Biology and Molecular Biophysics

    Structure and activation mechanism of the BBSome membrane protein trafficking complex

    Sandeep K Singh et al.
    Two cryo-EM structures of the mammalian BBSome show how the BBSome is recruited to membranes and activated by the GTPase ARL6 prior to binding transmembrane proteins.
    1. Cell Biology
    2. Plant Biology

    Integration of two RAB5 groups during endosomal transport in plants

    Emi Ito et al.
    Plant-unique RAB5 effector 2 (PUF2) is an effector of plant-unique ARA6, which plays a key role in plant endosomal transport, integrating functions of the two plant RAB5 groups by an unprecedented mechanism.
    1. Cell Biology

    Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding

    Jyothi S Akella et al.
    The RAB-28 GTPase regulates ciliary extracellular vesicle shedding, which may be important for neuron-glia communication.
    1. Chromosomes and Gene Expression

    Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation

    Assala Lamaa et al.
    The two H2A.Z isoforms have specific interactors which mediate their differential effects on gene expression.
    1. Cell Biology
    2. Neuroscience

    Microtubules originate asymmetrically at the somatic golgi and are guided via Kinesin2 to maintain polarity within neurons

    Amrita Mukherjee et al.
    The somatic Golgi acts as an asymmetric MTOC within Drosophila neurons, and this, together with the action Kinesin-2, helps maintain minus-end-out microtubule polarity with proximal dendrites.

Refine your results by:

Type
Research categories