Sloths, armadillos, and anteaters evolved genetic and cellular traits that make them remarkably cancer resistant.

Genetic and molecular analysis shows that Deltex modulates the Wingless gradient and counters Wingless signaling by promoting Armadillo/β-catenin degradation through a conserved regulatory mechanism.

Duplication of tumor suppressor genes contributed to the evolution of large, long-lived elephants.

Activating mutations in the leucine-rich repeat kinase 2 cause Parkinson’s disease, and an unbiased genome-wide screen revealed an unexpected, specific role for Rab12 in activating this kinase directly for Rab GTPase phosphorylation.

Parkinson’s disease-associated LRRK2 kinase is recruited to membranes by its Rab GTPase substrates, and LRRK2 is both retained on membranes and further activated there by cooperative interaction with the phosphorylated Rab proteins that it generates.

Elephants escaped enhanced cancer susceptibility by evolving more master tumor suppressor genes.

The glideosome-associated connector protein transitions between open and closed states, and this regulates its assembly and function during apicomplexan parasite motility.

Studying the genomes of mammals with sparse hair covering identifies specific genes and regulatory regions responsible for the formation of hair and skin, some of which were previously unrecognized.

In higher vertebrates, the position of the embryonic axis (the location at which gastrulation starts) is determined by the transcription factor Pitx2, which suggests that the mechanisms of this process, and hence those that regulate twinning, are related to those that set up the left–right axis.