1,358 results found
    1. Cell Biology

    Integrated control of transporter endocytosis and recycling by the arrestin-related protein Rod1 and the ubiquitin ligase Rsp5

    Michel Becuwe, Sébastien Léon
    A novel regulatory step in the endocytic pathway, which occurs post-internalization, takes place at the trans-Golgi network and involves the arrestin-related protein Rod1 and the ubiquitin ligase Rsp5.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence

    Christina FS Mages et al.
    Lin37 is essential for cell-cycle gene repression by the DREAM complex in cellular quiescence and a combined loss of Lin37 and Rb prevents cell-cycle exit in response to growth-limiting signals.
    1. Cancer Biology
    2. Cell Biology

    Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

    Sandra Kümper et al.
    The Rho kinases ROCK1 and 2 act redundantly in regulating cell proliferation and their depletion causes cellular senescence.
    1. Cancer Biology

    Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

    Ritu Chaudhary et al.
    Functional and mechanistic analysis of p53-regulated lncRNA PINCR and its interacting RNA-binding protein Matrin 3 uncovers context-dependent regulation of specific p53 target genes during DNA damage.
    1. Cell Biology

    53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

    Chii Shyang Fong et al.
    Tumor Protein p53 Binding Protein 1 and Ubiquitin Specific Peptidase 28 engage p53 to promote mitotic efficiency.
    1. Chromosomes and Gene Expression

    The dynamic assembly of distinct RNA polymerase I complexes modulates rDNA transcription

    Eva Torreira et al.
    Live-cell imaging, genetic analysis and electron cryomicroscopy identify structural motifs involved in the differential assembly of Pol I-Rrn3 complexes and Pol I homodimers in response to nutrient availability.
    1. Cell Biology
    2. Developmental Biology

    A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle

    Maria L Spletter et al.
    A developmental transcriptomics resource from Drosophila flight muscles quantifies the transcriptional dynamics during muscle morphogenesis and identifies three ordered phases of sarcomere morphogenesis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A ribosome assembly stress response regulates transcription to maintain proteome homeostasis

    Benjamin Albert et al.
    Ribosome assembly is monitored to promote proteostatis through a system whereby unassembled ribosomal proteins lead to activation of heat shock factor 1 and inactivation of the RP gene activator Ifh1.
    1. Biochemistry and Chemical Biology

    Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation

    Ryoji Miyazaki et al.
    Time-resolved and site-directed in vivo photo-crosslinking analysis of VemP allows identification of both cis- and trans-elements required for its regulated arrest-cancelation.
    1. Structural Biology and Molecular Biophysics

    Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis

    Sathish Ramakrishnan et al.
    Cooperative action of synaptotagmin and complexin is needed to arrest all SNARE complexes on a vesicle, and the reversal of the synaptotagmin clamp is sufficient to achieve fast, Ca2+-synchronized fusion.

Refine your results by:

Type
Research categories