137 results found
    1. Biochemistry and Chemical Biology

    Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

    Maria Carmela Filomena et al.
    Ablation of the sarcomeric protein myopalladin (MYPN), associated with human cardiomyopathies, results in dilated cardiomyopathy, which is severely aggravated by biomechanical stress, suggesting that skeletal myopathy patients carrying MYPN loss-of-function mutations may develop cardiomyopathy under conditions of cardiac stress.
    1. Medicine
    2. Microbiology and Infectious Disease

    An open label randomized controlled trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis

    Nguyen Thi Thuy Ngan et al.
    Despite evidence of significant anti-cryptococcal activity in vitro and animal models, including synergy with other antifungal agents, high-dose tamoxifen has no impact on cerebrospinal fluid sterilization in cryptococcal meningitis.
    1. Cell Biology

    KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

    Anthony A Ruberto et al.
    Krüppel-like factor 10 coordinates the hepatic circadian transcriptome and protects the liver from the adverse effects of increased sugar consumption.
    1. Developmental Biology

    Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

    Hyae Yon Kweon et al.
    Mice doubly deficient for Naa10 and Naa12 display embryonic lethality, with both enzymes compensating for each other with amino-terminal acetylation of proteins in mouse development.
    1. Stem Cells and Regenerative Medicine

    Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes

    Francis Grafton et al.
    Deep learning combined with induced pluripotent stem cell technology is an effective method to interrogate cellular phenotypes and predict patterns of cardiotoxicity in vitro.
    1. Cell Biology
    2. Medicine

    Adipocyte NR1D1 dictates adipose tissue expansion during obesity

    Ann Louise Hunter et al.
    Clock protein NR1D1 regulates white adipose tissue expansion and development of obesity-related pathology.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Identification of drugs associated with reduced severity of COVID-19 – a case-control study in a large population

    Ariel Israel et al.
    Large-scale retrospective analysis suggests medications and dietary supplements, such as rosuvastatin, ezetimibe, ubiquinone, risedronate, vitamin D, and magnesium, are associated with a lower rate of severe COVID-19 disease.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    A deep learning algorithm to translate and classify cardiac electrophysiology

    Parya Aghasafari et al.
    A deep learning network can classify cardiac myocytes into drug-free and drugged categories and predict the impact of electrophysiological perturbation across the continuum of aging.
    1. Cell Biology
    2. Medicine

    The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

    Yang Guo et al.
    The TRPM4 ion channel has been identified as an important component in the causation of mechanical pressure overload-induced pathological left ventricular hypertrophy, which is a powerful predictor of cardiovascular mortality.
    1. Biochemistry and Chemical Biology

    Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

    M'Lynn E Fisher et al.
    Activation of the sarcoplasmic reticulum calcium pump and enhancement of cellular calcium homeostasis by dwarf open reading frame reveal how this small membrane protein opposes phospholamban inhibitory function in cardiac muscle.

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