Current evidence does not suggest adverse effects of ACE inhibitors or ARBs in COVID-19 patients and, to the contrary, discontinuing these drugs in these patients may potentially be harmful.

Arterial myocyte PKD2 channels are activated by vasoconstrictor stimuli, which increases blood pressure, are upregulated during hypertension and cell-specific knockout in vivo reduces both physiological blood pressure and hypertension.

Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?

The activation mechanism of the nitric oxide receptor has been revealed by cryo-electron microscopy.

The RIPOSTE framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies.

A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.

The innexin protein UNC-7, a homologue of vertebrate pannexins, plays a specific, gap junction-independent role in C. elegans mechanosensation.

Engagement of both host and parasite signaling pathways proves a novel approach for developing improved anti-parasitic therapies.

Simultaneous phosphorylation of multiple substrate motifs drives switch-like target recognition and monoubiquitylation by an E3 ligase during metazoan development.

Attenuated anticipatory activity in ventromedial prefrontal cortex is modulated by dopamine D1 receptor density in nucleus accumbens, and accounts for impaired probabilistic reward learning in older adults.