Heat shock induces relocalization of epigenetic modifiers to the nucleolus, which acts as a dedicated protein quality control center that is indispensable for recovery of epigenetic regulators and epigenetic modifications.
The deletion of a single gene encoding a selective bile salt hydrolase from the abundant human gut bacterium Bacteroides thetaiotaomicron significantly alters host metabolism.
The adaptive value of social behaviour exhibited in adult life varies with conditions experienced in early life, and poorer conditions may promote conflict over cooperation.
Relion was used to solve structures of microtubules decorated with dynein microtubule-binding domains revealing that an axonemal dynein distorts the microtubule cross-sectional curvature.
Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.
Error detection is contingent on the continuation of evidence accumulation after choice commitment, and the speed and accuracy of this process are modulated by high-level signals from medial frontal cortex.
Delayed intramuscular gene therapy with neurotrophin-3 after corticospinal tract injury reduces spasticity and improves locomotion by treating underlying causes of spasticity.
Spatial attention and saccadic processing co-ordinate to ensure that attention is available at a task-relevant location soon after the beginning of each eye fixation.
