162 results found
    1. Immunology and Inflammation

    Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma

    Kenji Murata et al.
    A library of the paired peptide/HLA multimers and artificial APCs allows for construction of a large database of class I-restricted peptides and cognate tumor-reactive TCR genes at an unprecedented scale.
    1. Immunology and Inflammation

    Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

    Antonio P Baptista et al.
    MHC class II-mediated self-antigen presentation by lymph node stromal cells controls regulatory T cell homeostasis, thus safeguarding immune tolerance.
    1. Immunology and Inflammation
    2. Medicine

    Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis

    Shubhanshi Trivedi et al.
    Mucosal-associated invariant T (MAIT) cells, highly activated and dysfunctional in sepsis patients, contribute to tissue-specific cytokine responses that are protective against mortality during experimental sepsis.
    1. Immunology and Inflammation

    Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

    Michael Saitakis et al.
    Multiple functions of human T lymphocytes are shown to be potentiated within a wide range of physiological cell and tissue rigidities.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex

    Madeline G Andrews et al.
    mTOR signaling regulates the morphology of a human-enriched neural stem cell population and thus contributes to the radial architecture of the developing human cortex with implications for neurodevelopmental disease.
    1. Neuroscience

    Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior

    Sthitapranjya Pati et al.
    Enhanced Gq-signaling-mediated activation of forebrain excitatory neurons in postnatal life programs enhanced anxiety-, despair- and schizophrenia-like behavior, recapitulating key aspects of the behavioral consequences of early life adversity.
    1. Cell Biology
    2. Immunology and Inflammation

    Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

    Danielle J Clark et al.
    A membrane-associated, supramolecular protein complex with dynamically changing components, the central supramolecular activation cluster, regulates the generation of the T cell effector cytokine IL-2 depending on its composition.
    1. Immunology and Inflammation

    Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity

    Juan L Mendoza et al.
    Potential for specific microbiome-directed, MHC-restricted shaping of a commonly selected HIV-specific CD8+ T cell population was suggested by MHC class I yeast display-based peptide screening approaches.
    1. Microbiology and Infectious Disease

    Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii

    Alex Hunt et al.
    Partially overlapping functions of a limited subset of actin binding proteins allow the parasite Toxoplasma gondii to achieve actin regulation required for complex cellular processes.

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