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A novel RNA-based trans-regulatory system that control gene expression in mammalian cells has been developed and they can be coupled to endogenous signals.

A cell-sized fully confined space significantly controls the emergence and stability of a protein wave, resulting in intracellular spatiotemporal regulation driven by a reaction-diffusion mechanism.

A Syt1-tdTomato transgenic mice with normal synaptic transmission is established to label synapse in situ and screen synaptogenic adhesion molecules.

A chemical activator of the mechanosensitive Piezo1 ion channel has been identified.

A new python package standardises and simplifies how spatial behaviour and neural representations are modelled in continuous environments.

Chromatin remodelling is a key bottleneck to DNA end resection, the first and committed step of homologous recombination.

A multi-compartment spiking neural network model demonstrates that biologically feasible deep learning can be achieved if sensory inputs and higher-order feedback are received by different dendritic compartments.

Multiple functions of human T lymphocytes are shown to be potentiated within a wide range of physiological cell and tissue rigidities.

A new intricate reciprocity between microbiology and physics results in collective protection from desiccation through differential formation of stable microdroplets around bacterial aggregates on surfaces drying under moderate humidity.

A deep learning-based pipeline was developed for extracting cellular signals flexibly from moving cells in 3D time lapse images, and it outperformed previous methods under different imaging conditions.