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A mouse model of atopic dermatitis provides mechanistic evidence for an association between allergic disease and skin cancer.

A microbiome metabolite alleviates liver steatosis and inflammation, and shows its potential as a therapeutic modality for non-alcoholic fatty liver disease.

Hundreds of loci underlying ecological adaptation to different environmental conditions show striking differences in allele frequencies between ecotypes of Atlantic herring.

Organ-selective drug action of traditional Chinese medicine that generates systemic immune mediators is proposed and reviewed as a novel mechanistic angle to develop new immunomodulatory drugs.

A road to modulators of the kinase activity and the non-enzymatic functions of Src and IDO1 at once.

In-depth proteomic analyses of intestinal tissue-resident intraepithelial T lymphocytes reveals how these cells are adapted to the intestinal environment through increased cholesterol and lipid metabolism, tailored metabolic profiles, receptors for interacting with epithelial cells, and tightly regulated signalling pathways.

High cerebrospinal fluid tryptophan levels consistently predict increased mortality in HIV-infected and -uninfected patients in Vietnam and Indonesia.

Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.

The heterogeneity of immune cell types in glioblastoma tumors depends on the tumor's genetic make-up and treatment status and is an incompletely mined source of novel therapeutic targets.