Current models of Alzheimer's disease that put mitochondria as an endpoint of disease should be reconsidered because genetic defects affecting mitochondria by themselves can also regulate Alzheimer’s disease risk factor apolipoprotein E (APOE) expression and secretion.

Dysregulated unsaturated fatty acids and saturated fatty acids contribute to bacterial phenotypic resistance to antibiotics.

A computational method for predicting evolutionary pathways to antimicrobial resistance, accounting for how epistatic interactions determine trajectories, is described.

A single-cell RNA sequencing reveals cell heterogeneity of secondary metabolism in tea plant root and a proposed model in which the theanine biosynthesis pathway occurs via multicellular compartmentation.

Bacterial Type IV restriction-modification systems display remarkable, previously unnoticed diversity of complex gene and domain architectures, and are predicted to couple antiphage immunity with the abortive infection form of defense.

Structures of CysZ show a antiparallel membrane protein with an unanticipated fold and together with functional characterization provide insight into a bacterial sulfate translocating system.

Unique integrate stress response sensors differentially trigger pro-survival versus pro-apoptotic responses in cells confronted with Hsp70 inhibitor-associated proteotoxic challenges.