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    1. Structural Biology and Molecular Biophysics

    Structural basis of ribosomal peptide macrocyclization in plants

    Joel Haywood et al.
    The first crystal structure of an active plant asparaginyl endopeptidase reveals a tetrahedral intermediate state in its active site, which may help to explain why these enzymes have been independently recruited to perform peptide macrocyclization.
    1. Cell Biology
    2. Neuroscience

    Presenilin mutations deregulate mitochondrial Ca2+ homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans

    Shaarika Sarasija et al.
    In C. elegans, presenilin functions, independent of its gamma-secretase proteolytic activity, to regulate mitochondrial metabolism by controlling ER-mitochondrial calcium transfer and, even in the absence of Abeta signaling, loss of this activity leads to neurodegeneration.
    1. Physics of Living Systems

    Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

    Feng-Ching Tsai et al.
    Ezrin, an important actin-membrane linker, can zip adjacent membranes, be enriched to positively-curved membranes when phosphorylated and to negatively-curved membranes through a direct interaction with membrane curvature sensor I-BAR domain proteins.
    1. Cell Biology

    CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets

    Jordina Guillén-Boixet et al.
    CPEB4's switch from translational repressor to activator is regulated during cell cycle by hyperphosphorylation of its intrinsically disordered domain, which controls its phase-separation into RNA-containing liquid-like droplets.
    1. Human Biology and Medicine
    2. Neuroscience

    A Cryptochrome 2 mutation yields advanced sleep phase in humans

    Arisa Hirano et al.
    A missense mutation in the human Cryptochrome 2 (CRY2) gene leads to the condition of familial advanced sleep phase.
    1. Plant Biology

    Auxin efflux by PIN-FORMED proteins is activated by two different protein kinases, D6 PROTEIN KINASE and PINOID

    Melina Zourelidou et al.
    Two protein kinases are required to activate auxin efflux transporters from plants.
    1. Neuroscience

    Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

    Ming Chen et al.
    Experiments examining the actions of morphine on single neurons from one of the brain's reward centers, the VTA, reveal the mechanism by which the drug exerts its hedonic effects.
    1. Chromosomes and Gene Expression

    Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication

    FuJung Chang et al.
    Biochemical and genetic characterization of the Cdc6 replication initiator reveals similarities in the helicase loading reaction between bacteria and eukaryotes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS

    Tony Ly et al.
    A detailed analysis of protein abundance and phosphorylation changes across mitotic subphases and interphase in asynchronously growing human cells has been enabled by combining FACS with quantitative MS-based proteomics.
    1. Structural Biology and Molecular Biophysics

    Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

    Stefano Pernigo et al.
    X-ray crystallography reveals how kinesin-1 recognises a novel class of cargo adaptor motifs in an isoform-specific manner.