392 results found
    1. Microbiology and Infectious Disease
    2. Medicine

    A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

    Nguyen TH Mai et al.
    Adjunctive aspirin may reduce new brain infarcts and deaths in the first 60 days of treatment for HIV-uninfected adults with tuberculous meningitis.
  1. Meta-Research: How significant are the public dimensions of faculty work in review, promotion and tenure documents?

    Juan P Alperin et al.
    An analysis of review, promotion and tenure documents from 129 US and Canadian universities suggests institutions could better fulfill their public missions by changing how they incentivize the public dimensions of faculty work.
    1. Cell Biology

    Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation

    Duccio Conti et al.
    Human chromosome-microtubule attachments are stabilised by Astrin-mediated dynamic delivery of PP1 phosphatase to the attachment site, which ensures the normal segregation of chromosomes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80

    David M Kern et al.
    Biochemical and cell biological analyses reveal that the Astrin-SKAP complex acts to stabilize kinetochore-microtubule interactions through its intrinsic microtubule binding activity and its association with the Ndc80 complex, the core component of the kinetochore-microtubule interface.
    1. Computational and Systems Biology

    Meta-Research: Use of the Journal Impact Factor in academic review, promotion, and tenure evaluations

    Erin C McKiernan et al.
    Almost a quarter of faculty evaluation documents from US and Canadian universities mention Journal Impact Factor and often imply that it measures research quality.
    1. Microbiology and Infectious Disease

    Tuberculous Meningitis: Can aspirin help?

    Ashwini Kalantri, Shriprakash Kalantri
    Using a combination of aspirin, anti-tuberculosis drugs and steroids may help to reduce the number of strokes and deaths in patients with tuberculous meningitis.
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    1. Ecology

    Parental effects alter the adaptive value of an adult behavioural trait

    Rebecca M Kilner et al.
    The adaptive value of social behaviour exhibited in adult life varies with conditions experienced in early life, and poorer conditions may promote conflict over cooperation.
    1. Cancer Biology
    2. Cell Biology

    Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior

    Rochelle Shirin Sadeghi et al.
    Phosphorylation of serine residues 209 and 210 on APT1 increases its depalmitoylating activity, promoting Wnt5a mediated melanoma cell invasion.
    1. Cancer Biology

    Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

    Kotaro Shirakawa et al.
    Salicylic acid, the precursor to aspirin, is an anti-tumor agent that blocks protein acetylation.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Microbial genetic and transcriptional contributions to oxalate degradation by the gut microbiota in health and disease

    Menghan Liu et al.
    A novel multi-omics framework revealed the taxonomic contribution to microbiota oxalate, demontrated O. formigenes as the dominating taxon transcriptionally, and identified specific IBD cohort at risk for oxalte toxicity.

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