83 results found
    1. Human Biology and Medicine
    2. Neuroscience

    High performance communication by people with paralysis using an intracortical brain-computer interface

    Chethan Pandarinath et al.
    New computer algorithms have allowed people with paralysis to achieve the highest reported typing performance using a brain-computer interface.
    1. Neuroscience

    Augmented reality powers a cognitive assistant for the blind

    Yang Liu et al.
    A non-invasive cognitive assistant for blind people endows objects in the environment with voices, allowing users to explore the scene, localize objects, and navigate through a building with minimal training.
    1. Human Biology and Medicine

    Point of View: How should the applications of genome editing be assessed and regulated?

    Robin Fears, Volker ter Meulen
    An EASAC working group on genome editing recommends that regulators should focus on specific applications of these new techniques rather than attempting to regulate genome editing itself as a new technology.
    1. Cell Biology
    2. Human Biology and Medicine

    A role for PVRL4-driven cell–cell interactions in tumorigenesis

    Natalya N Pavlova et al.
    A protein called PVRL4 has a central role in a number of cancers that originate in epithelial tissue, and anti-PVRL4 antibodies could be used to treat some of these cancers.
    1. Cell Biology
    2. Immunology and Inflammation

    Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

    Sudha Kumari et al.
    T cell receptor signaling is regulated by newly polymerized F-actin foci at the immunological synapse.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cofilin-induced unidirectional cooperative conformational changes in actin filaments revealed by high-speed atomic force microscopy

    Kien Xuan Ngo et al.
    A cluster of cofilin along an otherwise bare actin filament induces distinctively asymmetric cooperative conformational changes to the filament on either side of the cluster.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Super Spy variants implicate flexibility in chaperone action

    Shu Quan et al.
    Lab-evolved 'super Spy' chaperones show enhanced flexibility, which allows them to bind to and stabilize proteins more effectively than natural chaperones.
    1. Developmental Biology

    Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1

    David Kimelman et al.
    Analysis of a double mutant in the Hippo pathway transcription factors Yap1 and Wwtr1 reveals novel roles for these factors in posterior body formation and epidermal morphogenesis in the vertebrate embryo.
    1. Epidemiology and Global Health

    External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh

    Malia SQ Murphy et al.
    Gestational age estimation models derived from newborn screening bloodspot samples are effective on data obtained from both heel prick and cord blood samples in low-resource settings.
    1. Physics of Living Systems

    Developmental adaptations of trypanosome motility to the tsetse fly host environments unravel a multifaceted in vivo microswimmer system

    Sarah Schuster et al.
    Trypanosome development within the transmitting tsetse fly reveals essential adaptations of microbial motility to diverse physical microenvironments.

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