6,554 results found
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

    Agata Wesolowska-Andersen, Grace Zhuo Yu ... Mark I McCarthy
    Combination of deep learning models trained on tissue-specific genomic data and fine-mapping approaches supports efforts to identify causal variants and mechanisms at GWAS loci.
    1. Genetics and Genomics
    2. Medicine

    Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

    Yi Liu, Nicolas Basty ... Madeleine Cule
    Systematic quantification of abdominal organ health parameters using deep learning generates new insights into the genetic architecture of cardiometabolic health traits.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Haplotype function score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits

    Weichen Song, Yongyong Shi, Guan Ning Lin
    Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.
    1. Neuroscience

    Higher-order unimodal olfactory sensory preconditioning in Drosophila

    Juan Martinez-Cervantes, Prachi Shah ... Isaac Cervantes-Sandoval
    Drosophila flies infer value to olfactory stimuli based on the previously repeatedly presented associative structure between two odorants.
    1. Computational and Systems Biology
    2. Neuroscience

    Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans

    Rany Abend, Diana Burk ... Bruno B Averbeck
    Applying computational modeling to quantify threat learning processes uncovers how variations in these conserved learning processes relate to anxiety severity and the neuroanatomical substrates moderating these associations.
    1. Neuroscience

    Critical role for the mediodorsal thalamus in permitting rapid reward-guided updating in stochastic reward environments

    Subhojit Chakraborty, Nils Kolling ... Anna S Mitchell
    In monkeys, the integrity of the magnocellular subdivision of mediodorsal thalamus is important when using recent rewarded choices to promote persistence with a recently sampled choice during changing or uncertain reward guided-learning and decision-making tasks.
    1. Neuroscience

    Vicarious reward unblocks associative learning about novel cues in male rats

    Sander van Gurp, Jochen Hoog ... Marijn van Wingerden
    Rats learn to interpret cues predicting rewards delivered to social partners as valuable, but only if social information exchange is possible.
    1. Neuroscience

    Associative learning changes cross-modal representations in the gustatory cortex

    Roberto Vincis, Alfredo Fontanini
    Cross-modal stimuli are represented in the primary gustatory cortex according to their sensory identity, associability and predictive value.
    1. Neuroscience

    A molecular mechanism underlying gustatory memory trace for an association in the insular cortex

    Chinnakkaruppan Adaikkan, Kobi Rosenblum
    The role of CaMKII-GluA1 in the cortex in maintaining a given taste memory trace for an aversive association has been elucidated.
    1. Neuroscience

    LTD at amygdalocortical synapses as a novel mechanism for hedonic learning

    Melissa S Haley, Stephen Bruno ... Arianna Maffei
    Taking advantage of awell-established learning paradigm, conditioned taste aversion (CTA), change of hedonic value of a palatable tastant revealed the neural mechanisms encoding this learning process.

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