44 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genomic footprint of social stratification in admixing American populations

    Alex Mas-Sandoval, Sara Mathieson, Matteo Fumagalli
    Social hierarchies resulting from the European colonization of the Americas stratified the population structure, leading to ancestry-related assortative mating and sex bias patterns that can be inferred from the genomes of the populations across the continent.
    1. Genetics and Genomics

    Variable prediction accuracy of polygenic scores within an ancestry group

    Hakhamanesh Mostafavi, Arbel Harpak ... Molly Przeworski
    The prediction accuracies of polygenic scores in humans vary depending on the characteristics of the samples, as well as based on the study design, within a single ancestry group.
    1. Epidemiology and Global Health

    Weakening of the cognition and height association from 1957 to 2018: Findings from four British birth cohort studies

    David Bann, Liam Wright ... Vanessa Moulton
    The link between height and cognitive assessment scores substantially weakened from 1957 to 2018.
    1. Evolutionary Biology

    Recent shifts in the genomic ancestry of Mexican Americans may alter the genetic architecture of biomedical traits

    Melissa L Spear, Alex Diaz-Papkovich ... Ryan D Hernandez
    Admixture dynamics have recently changed over time in Mexican Americans resulting in an impact on the genetic architecture of phenotypic variation.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study

    Amanda M Hughes, Eleanor Sanderson ... Neil M Davies
    It is unclear how much a child's BMI at age 8 affects their depressive and ADHD symptoms after family-level factors are accounted for, but a substantial impact on anxiety symptoms is unlikely.
    1. Genetics and Genomics

    An oligogenic architecture underlying ecological and reproductive divergence in sympatric populations

    Dušica Briševac, Carolina M Peralta, Tobias S Kaiser
    In the marine midge Clunio marinus, sympatric ecological population divergence with gene flow is based on at least four genetic loci, which partially overlap with large chromosomal inversions.
    1. Ecology

    Parental effects alter the adaptive value of an adult behavioural trait

    Rebecca M Kilner, Giuseppe Boncoraglio ... Hanna Kokko
    The adaptive value of social behaviour exhibited in adult life varies with conditions experienced in early life, and poorer conditions may promote conflict over cooperation.
    1. Genetics and Genomics

    Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes

    Liang-Dar Hwang, Gunn-Helen Moen, David M Evans
    Adopted individuals in large-scale population based cohorts can be leveraged to partition maternal genetic effects into prenatal and postnatal components, helping elucidate the underlying mechanisms behind these associations, and for diseases, yielding important information regarding the optimal timing of interventions.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study

    Laurence J Howe, Ben Brumpton ... Neil M Davies
    Genetic data from siblings provides strong evidence that taller height increases the risk of cancers but lowers the risk of coronary disease.
    1. Epidemiology and Global Health

    Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health

    Neil Martin Davies, W David Hill ... George Davey Smith
    Many of the effects of intelligence on health and social outcomes later in life are mediated via education.

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