330 results found
    1. Computational and Systems Biology

    Trajectories of childhood immune development and respiratory health relevant to asthma and allergy

    Howard HF Tang et al.
    Unsupervised cluster analysis identified similar groups of children in different cohorts, with distinct developmental patterns of immunorespiratory health, asthma and allergy.
    1. Epidemiology and Global Health
    2. Medicine

    Risk factors for asthma among schoolchildren who participated in a case-control study in urban Uganda

    Harriet Mpairwe et al.
    Asthma risk among schoolchildren increases depending on area of residence in early life, from rural to town to city, and this risk increases further with other known risk factors.
    1. Genetics and Genomics

    Psychosocial experiences modulate asthma-associated genes through gene-environment interactions

    Justyna A Resztak et al.
    Psychosocial environments modulate genetic risk of asthma and other allergic diseases through altered peripheral blood gene expression.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants

    Katina D Hulme et al.
    Patients with paucigranulocytic asthma may be more susceptible to severe influenza and could potentially be source of new, more virulent, influenza virus variants.
    1. Immunology and Inflammation
    2. Medicine

    Bacterial–fungal interactions in the neonatal gut influence asthma outcomes later in life

    Rozlyn CT Boutin et al.
    Overgrowth of the yeast Pichia kudriavzevii within the neonatal gut microbiota increases allergic airway disease severity later in life and may be inhibited by short-chain fatty acids.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma

    Jaisy Arikkatt et al.
    HMGB1 drives the development of paucigranulocytic asthma in RAGE deficient mice.
    1. Immunology and Inflammation
    2. Medicine

    Perinatal granulopoiesis and risk of pediatric asthma

    Benjamin A Turturice et al.
    Perinatal granulopoiesis and cord blood serum PGLYRP-1, a specific granule protein, are altered prior to onset of childhood asthma and provide potential targets for early identification of at-risk populations.
    1. Microbiology and Infectious Disease

    A type III-A CRISPR-Cas system employs degradosome nucleases to ensure robust immunity

    Lucy Chou-Zheng, Asma Hatoum-Aslan
    Degradosome-associated nucleases PNPase and RNase J2 are required for type III CRISPR immunity against diverse nucleic acid invaders originating from plasmid and phage.
    1. Computational and Systems Biology

    The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture

    Athma A Pai et al.
    Surprising connections between gene architecture and splicing kinetics are illuminated using short, progressive metabolic labeling/RNA sequencing and novel computational modeling approaches in Drosophila cells.
    1. Developmental Biology

    Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo

    Jacques P Bothma et al.
    Quantitative live imaging assays reveal that multiple enhancers often fail to work in an additive fashion in the patterning of the Drosophila embryo, and sometimes even interfere with one another.

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