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A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell
Lori Clay et al.
Sphingolipids govern the compartmentalization of yeast cells through the assembly of lateral diffusion barriers in ER membranes.
acts in the PLK1-dependent spindle positioning pathway and supports neural development
Marisa Connell et al.
HMMR regulates spindle positioning in neural and other cell types downstream of PLK1 and subsequently affects cortical NuMA-Dynein localization.
The ER Stress Surveillance (ERSU) pathway regulates daughter cell ER protein aggregate inheritance
Francisco J Piña, Maho Niwa
Endoplasmic reticulum (ER) inheritance regulation during ER stress controls the transmission of misfolded ER proteins from mother to daughter cell in budding yeast.
Protein aggregates are associated with replicative aging without compromising protein quality control
Juha Saarikangas, Yves Barral
The aging lineage of budding yeast is differentiated by an early-appearing protein deposit that promotes protein quality control.
aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in
Matthew Robert Hannaford et al.
The actomyosin network and phospho-regulation combine to polarize fate determinants at the Drosophila neuroblast cell cortex.
Asymmetric recruitment and actin-dependent cortical flows drive the neuroblast polarity cycle
Chet Huan Oon, Kenneth E Prehoda
Neural stem cells dynamically polarize through the stepwise activity of polarized cortical targeting and cortical flows that coalescence discontinuous cortical patches into an organized cap structure.
Computational and Systems Biology
Remote control of microtubule plus-end dynamics and function from the minus-end
Xiuzhen Chen et al.
A mechanism for yeast centrosomes to differentiate the microtubule cytoskeleton.
NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures
Lindsey Seldin et al.
A newly identified microtubule binding activity of NuMA is required for orienting the mitotic spindle.
Anterior CNS expansion driven by brain transcription factors
Jesús Rodriguez Curt et al.
The expansion of the anterior Drosophila CNS is driven by increased progenitor generation and prolonged proliferation, mediated by brain-restricted genes and the PRC2.
Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2
Pierluigi Scerbo et al.
Degradation and asymmetric inheritance during cell division of a core pluripotency regulator contributes to lineage commitment in the early
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