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    1. Stem Cells and Regenerative Medicine

    Cell Division: Sibling cell size matters

    Clemens Cabernard
    A motor protein called Klp10A ensures that germline stem cells in male fruit flies divide to produce two sibling cells that are equal in size.
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    1. Cell Biology
    2. Developmental Biology

    HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development

    Marisa Connell et al.
    HMMR regulates spindle positioning in neural and other cell types downstream of PLK1 and subsequently affects cortical NuMA-Dynein localization.
    1. Cell Biology

    A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell

    Lori Clay et al.
    Sphingolipids govern the compartmentalization of yeast cells through the assembly of lateral diffusion barriers in ER membranes.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche

    Kacy L Gordon et al.
    A previously undetected dynamic cell structure orients the mitotic spindle of germ stem cells and grows over one daughter cell, thus helping to balance niche retention with niche exit.
    1. Cell Biology
    2. Developmental Biology

    Telophase correction refines division orientation in stratified epithelia

    Kendall J Lough et al.
    Telophase reorientation corrects errors in spindle orientation that persist after imprecise initial spindle positioning during early mitosis, and contributes to balancing self-renewal with differentiation during epidermal development.
    1. Cell Biology
    2. Computational and Systems Biology

    Remote control of microtubule plus-end dynamics and function from the minus-end

    Xiuzhen Chen et al.
    A mechanism for yeast centrosomes to differentiate the microtubule cytoskeleton.
    1. Cell Biology
    2. Developmental Biology

    Asymmetric recruitment and actin-dependent cortical flows drive the neuroblast polarity cycle

    Chet Huan Oon, Kenneth E Prehoda
    Neural stem cells dynamically polarize through the stepwise activity of polarized cortical targeting and cortical flows that coalescence discontinuous cortical patches into an organized cap structure.
    1. Developmental Biology

    aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts

    Matthew Robert Hannaford et al.
    The actomyosin network and phospho-regulation combine to polarize fate determinants at the Drosophila neuroblast cell cortex.
    1. Cell Biology
    2. Developmental Biology

    Protein aggregates are associated with replicative aging without compromising protein quality control

    Juha Saarikangas, Yves Barral
    The aging lineage of budding yeast is differentiated by an early-appearing protein deposit that promotes protein quality control.
    1. Cell Biology

    The ER Stress Surveillance (ERSU) pathway regulates daughter cell ER protein aggregate inheritance

    Francisco J Piña, Maho Niwa
    Endoplasmic reticulum (ER) inheritance regulation during ER stress controls the transmission of misfolded ER proteins from mother to daughter cell in budding yeast.