963 results found
    1. Cell Biology

    Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability

    Ana Maria G Dumitru et al.
    Quantitative phosphoproteomics defines the substrates for Cyclin A/Cdk1 kinase during early mitosis and follow up studies validate that one identified substrate, MYPT1, influences the stability of k-MT attachments by regulating Plk1.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane

    Pascal Weber et al.
    A step of contact establishment preceding stable membrane attachment by palmitoylation is identified.
    1. Cell Biology
    2. Developmental Biology

    Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment in Drosophila

    Hannah J Green et al.
    Integrin and actin associated proteins are resolved into four layers within myofibril attachments, an architecture requiring balanced positive and negative regulation of integrin adhesion with integrated mechanotransduction and actin pathways.
    1. Cell Biology
    2. Developmental Biology

    Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions

    Arul Subramanian, Thomas F Schilling
    Functional attachments between muscles and tendons require pentameric Thrombospondin-4, revealing novel roles both as an integrin ligand and extracellular matrix scaffold.
    1. Cell Biology

    Cortical dynein pulling mechanism is regulated by differentially targeted attachment molecule Num1

    Safia Omer et al.
    Dynein-dependent microtubule-cortex interactions – "side-on" versus "end-on" pulling – are regulated by cortical ER and mediated by distinct pools of cortical anchor that are differentially localized along the cell periphery.
    1. Cell Biology

    Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments

    Tae Yeon Yoo et al.
    Quantitative experiments and theory show that the tension-dependent regulation of NDC80 binding to kinetochore microtubules arises from a combination of the changing Aurora B concentration at NDC80 and the nonlinearity of Aurora B autoactivation.
    1. Cell Biology
    2. Computational and Systems Biology

    Human kinetochores are swivel joints that mediate microtubule attachments

    Chris A Smith et al.
    The outer domain of the kinetochore can rotate (swivel) around the centromere, and this rather than intra-kinetochore stretching is coupled to anaphase onset.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

    Benjamin A Smith et al.
    New insights into the mechanism responsible for the nucleation of branches on networks of actin filaments shed light on a process that is essential for eukaryotic cell motility and endocytosis.
    1. Microbiology and Infectious Disease

    Visualizing trypanosomes in a vertebrate host reveals novel swimming behaviours, adaptations and attachment mechanisms

    Éva Dóró et al.
    The transparent zebrafish reveals the reality of trypanosomes swimming in a vertebrate host, and their adaptations to an extremely heterogenic environment.
    1. Developmental Biology
    2. Neuroscience

    Frazzled promotes growth cone attachment at the source of a Netrin gradient in the Drosophila visual system

    Orkun Akin, S Lawrence Zipursky
    Direct observation in the developing fly brain indicates that the response of a growth cone in a gradient of a guidance cue is adhesion to the source of the cue rather than attraction by the gradient.

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