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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1

    Fahad Rashid et al.
    Structure specific nucleases that act in DNA replication, repair and recombination actively mold their DNA while transforming their own structure to achieve precise cleavage of their cognate DNA and avoid the deleterious cleavage of noncognate DNA.
    1. Developmental Biology
    2. Neuroscience

    Neuronal cell fate diversification controlled by sub-temporal action of Kruppel

    Johannes Stratmann et al.
    A combination of temporal and sub-temporal genes combine to move the stem cell through different competence windows to generate different cell types at different time-points in Drosophila.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link

    Huyen Nguyen et al.
    The presence of certain HLA alleles drives the emergence or maintenance of otherwise deleterious drug-resistant mutations in patients living with HIV, even when the patient is antiretroviral treatment naïve.
    1. Epidemiology and Global Health

    Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites

    Qianxi Feng et al.
    Familial cancer clustering was significantly higher in US minority populations compared to those of US European origin, suggesting renewed need for a focus on family cancer predisposition in US Latinos, Blacks, and Asian/Pacific Islanders.
    1. Neuroscience

    The nature of the animacy organization in human ventral temporal cortex

    Sushrut Thorat et al.
    The animacy organization in human ventral visual cortex is driven by both the presence of animal-diagnostic visual features and the psychological property of agency.
    1. Cancer Biology
    2. Cell Biology

    A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

    Francesca Angiolini et al.
    Endothelial cells express a soluble isoform of the L1CAM cell adhesion molecule that is generated by the splicing factor NOVA2 and induces angiogenesis, with relevant implications for ovarian cancer vascularization.
    1. Computational and Systems Biology

    Spatiotemporal establishment of dense bacterial colonies growing on hard agar

    Mya R Warren et al.
    A 3D model captures the growth and expansion dynamics of bacterial colonies, revealing distinct effects of surface tension, mechanical forces, and nutrients on the speed of radial and vertical expansion.
    1. Neuroscience

    Distinct spatial coordinate of visual and vestibular heading signals in macaque FEFsem and MSTd

    Lihua Yang, Yong Gu
    In both frontal and temporal–parietal visual cortices of macaque, distinct spatial coordinates of visual and vestibular signals are predominantly eye centered and head centered, respectively.
    1. Structural Biology and Molecular Biophysics

    Domain–domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel

    Mark A Zaydman et al.
    Contrary to a generally accepted principle, the pore properties of KCNQ1 channels depend on the states of voltage-sensing domains activation; KCNE1 alters the voltage-sensing domains-pore coupling to modulate KCNQ1 channel properties.
    1. Epidemiology and Global Health
    2. Medicine

    A high rate of COVID-19 vaccine hesitancy in a large-scale survey on Arabs

    Eyad A Qunaibi et al.
    Providing important data regarding the proportion of COVID-19 vaccine hesitancy and barriers toward vaccination in Arabic-speaking people to guide addressing the problem and achievement of widespread vaccination and collective immunity.