178 results found
    1. Cell Biology

    Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes

    Sakshi Shambhavi, Sudipta Mondal ... Rajan Sankaranarayanan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Evolutionary Biology
    2. Genetics and Genomics

    Insights into early animal evolution from the genome of the xenacoelomorph worm Xenoturbella bocki

    Philipp H Schiffer, Paschalis Natsidis ... Maximilian J Telford
    A genome analysis of Xenoturbella bocki provides insights into the biology of this enigmatic marine worm and enhances our understanding of early bilaterian evolution.
    1. Neuroscience

    Striatal cholinergic interneuron pause response requires Kv1 channels, is absent in dyskinetic mice, and is restored by dopamine D5 receptor inverse agonism

    Cecilia Tubert, Rodrigo M Paz ... Mario G Murer
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology

    Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

    Anne Fajac, Iva Simeonova ... Franck Toledo
    The male-specific tumor-suppressive effects of minor p53 isoforms were correlated with higher Ackr4 expression levels, which have implications for sex-specific cancer prognosis in humans.
    1. Stem Cells and Regenerative Medicine

    Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila

    Zhixin Ma, Wenshu Wang ... Su Wang
    Iron content in neural stem cells controlled by glial ferritin is critical for self-renewal and proliferation of neural stem cells.
    1. Neuroscience

    Connectome-Based Attractor Dynamics Underlie Brain Activity in Rest, Task, and Disease

    Robert Englert, Balint Kincses ... Tamas Spisak
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Developmental Biology

    Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

    Akiko Hozumi, Nozomu M Totsuka ... Yasunori Sasakura
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Semantic plasticity across timescales in the human brain

    Sarah H Solomon, Kendrick Kay, Anna C Schapiro
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

    Julia Ruge, Mana R Ehlers ... Tina B Lonsdorf
    Individuals with a history of adverse childhood experiences show blunted response to threat and reward irrespective of sample and paradigm characteristics and despite heterogeneity in adversity operationalization and assessment.
    1. Biochemistry and Chemical Biology

    Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy

    Boglarka Zambo, Evelina Edelweiss ... Gergo Gogl
    The SH3 domain of BIN1 mediates an unexpectedly large array of interactions, which is perturbed by missense variants.
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