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    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Genomic epidemiology of COVID-19 in care homes in the east of England

    William L Hamilton, Gerry Tonkin-Hill ... COVID-19 Genomics Consortium UK
    SARS-CoV-2 can spread efficiently within care homes causing outbreaks among residents, who are at increased risk of severe disease, emphasising the importance of stringent infection control in this population.
    1. Epidemiology and Global Health
    2. Medicine

    Type 2 diabetes mellitus accelerates brain aging and cognitive decline: Complementary findings from UK Biobank and meta-analyses

    Botond Antal, Liam P McMahon ... Lilianne R Mujica-Parodi
    Patients with Type 2 diabetes show patterns of neurodegeneration consistent with accelerated brain aging, including impaired cognition and loss of brain volume, which are more severe in those with increased disease duration.
    1. Cancer Biology

    AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer

    Seaho Kim, CheukMan C Au ... Paraskevi Giannakakou
    Advanced microscopy techniques reveal unique biological features that distinguish androgen receptor variant 7 (AR-V7) from the canonical AR, including high intranuclear mobility and rapid nuclear import that occurs independently of importin-α/β.
    1. Ecology

    Wind prevents cliff-breeding birds from accessing nests through loss of flight control

    Emily Shepard, Emma-Louise Cole ... Andrew Ross
    Even moderate winds cause auks to abort landing attempts at nest-sites, and as a result, wind characteristics may affect where these, and other seabirds, choose to breed.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Dissection of specific binding of HIV-1 Gag to the 'packaging signal' in viral RNA

    Mauricio Comas-Garcia, Siddhartha AK Datta ... Alan Rein
    While HIV-1 Gag protein binds tightly to several RNAs, it binds to the viral RNA 'packaging signal' with higher specificity than to control RNAs.
    1. Epidemiology and Global Health
    2. Medicine

    Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

    Heli Julkunen, Anna Cichońska ... Nightingale Health UK Biobank Initiative
    Metabolic biomarkers measured from single blood test can identify apparently healthy people at high susceptibility for developing severe pneumonia, and may also be useful for preventive COVID-19 screening.
    1. Epidemiology and Global Health

    Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health

    Neil Martin Davies, W David Hill ... George Davey Smith
    Many of the effects of intelligence on health and social outcomes later in life are mediated via education.
    1. Epidemiology and Global Health

    Inference of the SARS-CoV-2 generation time using UK household data

    William S Hart, Sam Abbott ... Robin N Thompson
    Updated estimates of the generation time of SARS-CoV-2 infections indicate that the generation time has become shorter.
    1. Neuroscience

    Two human brain systems micro-structurally associated with obesity

    Manfred G Kitzbichler, Daniel Martins ... Neil A Harrison
    Revealing two distinct brain systems linked to obesity, this research illuminates the intricate relationship between obesity, brain microstructure and genetics with potential implications for treatment and prevention.
    1. Medicine
    2. Neuroscience

    Point of View: Open science takes on Parkinson’s disease

    Ekemini AU Riley, Randy Schekman
    The ASAP initiative promotes open and collaborative practices, and works with other foundations and projects in an effort to understand the mechanisms responsible for the onset and progression of Parkinson's.