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    1. Stem Cells and Regenerative Medicine

    Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

    Stephanie F Bellmaine et al.
    Small molecule inhibition of stem cell differentiation in vitro provides novel insight into how DYRK1A loss disrupts human nervous system development.
    1. Neuroscience

    How prior preferences determine decision-making frames and biases in the human brain

    Alizée Lopez-Persem et al.
    Model-based analyses of choice behavior and fMRI activity revealed that prior preferences generate default policies, which frame the decision value signal encoded in the vmPFC, and shift vmPFC pre-choice activity so as to induce a decision bias toward default options.
    1. Neuroscience

    Amygdala neural activity reflects spatial attention towards stimuli promising reward or threatening punishment

    Christopher J Peck, C Daniel Salzman
    Primate amygdala neurons provide a coordinated representation of space and motivational significance whereby amygdala responses to visual stimuli predicting either rewards or aversive stimuli could influence spatial attention in a similar manner.
    1. Neuroscience

    Fast transient networks in spontaneous human brain activity

    Adam P Baker et al.
    Non-invasive MEG recordings reveal that patterns of spontaneous activity in the resting brain are shorter lived than previously thought.
    1. Neuroscience

    Real-time experimental control using network-based parallel processing

    Byounghoon Kim et al.
    The Real-Time Experimental Control with Graphical User Interface (REC-GUI) framework can facilitate cutting-edge neuroscience research by providing precise experimental control using high-level programming environments familiar to many experimentalists.
    1. Computational and Systems Biology
    2. Neuroscience

    FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch

    Zachary Daniel Burkett et al.
    Basal ganglia gene coexpression patterns shift across the sensorimotor critical period for vocal learning.
    1. Neuroscience

    Cell-specific gain modulation by synaptically released zinc in cortical circuits of audition

    Charles T Anderson et al.
    Synaptic zinc is a novel modulator of cortical sound processing - a modulator that increases the gain of principal neurons, but reduces the gain of interneurons.
    1. Cell Biology
    2. Neuroscience

    Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory

    Yang Niu et al.
    SNX6 regulates the distribution of a protein called Homer1b/c to distal dendrites, enabling the latter to stabilize the synapses and thereby support memory formation.
    1. Cell Biology
    2. Immunology and Inflammation

    Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

    Anthony J Covarrubias et al.
    Interleukin 4 signaling co-opts the Akt-mTORC1-Acly pathway to couple metabolic input to the control of energetically demanding processes during macrophage M2 activation.
    1. Neuroscience

    Two-photon imaging in mice shows striosomes and matrix have overlapping but differential reinforcement-related responses

    Bernard Bloem et al.
    Simultaneous 2-photon imaging of striosomes and matrix in mice shows that striosomes preferentially encode reward-predicting cues whereas both striatal compartments demonstrate reward-related activity.