25 results found
    1. Medicine
    2. Immunology and Inflammation

    Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq

    Sara E Vazquez et al.
    Humans with mutations in the AIRE gene exhibit common autoantibodies targeting ovarian and intestinal antigens, including intestinal dysfunction-associated antibodies to enteroendocrine transcription factor RFX6.
    1. Immunology and Inflammation

    Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells

    Isaac J Jensen et al.
    Sepsis-induced numerical loss of naive autoantigen-specific CD4 T cells reduces host capacity to develop autoimmune immune disease, thereby demonstrating an intriguing relationship between infection and autoimmune disease.
    1. Immunology and Inflammation

    Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

    Nils Landegren et al.
    We are writing to comment on the study by Meyer et al., 2016 on disease-ameliorating autoantibodies.
    1. Immunology and Inflammation

    Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

    Christina Hertel et al.
    We are writing to reply to the comment by Landegren et al., 2019 about our study (Meyer et al., 2016) on disease-ameliorating autoantibodies.
    1. Immunology and Inflammation

    Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

    Yasunobu Arima et al.
    A link between chronic stress and organ dysfunction is explained by the gateway reflex, in which brain micro-inflammation at specific vessels establishes a new neural pathway to induce fatal organ failure particularly in gastrointestine and heart.
    1. Immunology and Inflammation

    TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

    Marije Baas et al.
    The interplay between the cytokine TGFβ and the PD-1/PD-L1 pathway promotes CD8+ T cell anergy and tolerance towards transplanted tissues.
    1. Immunology and Inflammation

    Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function

    Marie Bettonville et al.
    Long-term exposure to recipient's alloantigens promotes major metabolic defects in T cells that are independent of PD-1-mediated regulation.
    1. Cell Biology
    2. Immunology and Inflammation

    Galectin-9 regulates the threshold of B cell activation and autoimmunity

    Logan K Smith et al.
    Galectin-9-deficient mice develop spontaneous autoimmunity, driven by a decreased threshold of B cell activation and enhanced auto-antigen delivery to the spleen by increased B1a-derived autoantibodies.
    1. Immunology and Inflammation

    A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

    Yasunobu Arima et al.
    Pain sensation induces relapse in a mouse model of multiple sclerosis via a sensory-sympathetic signaling pathway.
    1. Immunology and Inflammation

    IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

    Mark Noviski et al.
    Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.

Refine your results by:

Type
Research categories