51 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Autocatalytic microtubule nucleation determines the size and mass of Xenopus laevis egg extract spindles

    Franziska Decker et al.
    Quantitative microscopy and theory show that the size of Xenopus laevis egg extract spindles is controlled by a spatially-regulated autocatalytic growth mechanism driven by microtubule-stimulated microtubule nucleation.
    1. Cell Biology
    2. Developmental Biology

    Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

    Sabine Schürmann et al.
    Proteolysis of lipidated N-terminal peptides that tether Hedgehog morphogens to the surface of source cells is absolutely required for their coupled release and bioactivation in vivo in Drosophila melanogaster.
    1. Ecology

    Dynamic metabolic exchange governs a marine algal-bacterial interaction

    Einat Segev et al.
    Physical and chemical interactions with bacteria influence the life and death of Emiliania huxleyi, a bloom-forming micro-alga important in global biogeochemical cycles.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells

    Ananya Mukherjee et al.
    Unique biosensor design and protein-engineering enables direct visualization of the active form of Fyn kinase with high specificity, minimal perturbation and shows cellular signaling to be compartmentalized and pulsatile.
    1. Cell Biology

    Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes

    Natalia Wesolowska et al.
    Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.
    1. Cell Biology
    2. Physics of Living Systems

    Spatiotemporal organization of branched microtubule networks

    Akanksha Thawani et al.
    A sequential reaction pathway involving TPX2, augmin and γ-TuRC governs the assembly and architecture of branched microtubule networks.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response

    Harshad Ghodke et al.
    Phase separated DNA-free stored forms of RecA dissolve in response to DNA damage to make RecA available for repair and recombination reactions as part of the bacterial (Escherichia coli) SOS response.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

    Ioanna Oikonomidi et al.
    Secretion of the inflammatory cytokine TNF requires a protein called iTAP/FrmD8, which controls the cell surface stability of the TNF shedding machinery, iRhom2 and TACE/ADAM17.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation

    Fabienne Lampert et al.
    Proteomic, biochemical and cell-based analyses of the heterodecameric core GID/CTLH E3 ligase complex reveal its molecular architecture, activity determinants, and function in targeting the tumor suppressor Hbp1 and other substrates required for cell proliferation.
    1. Structural Biology and Molecular Biophysics

    Structural basis of ribosomal peptide macrocyclization in plants

    Joel Haywood et al.
    The first crystal structure of an active plant asparaginyl endopeptidase reveals a tetrahedral intermediate state in its active site, which may help to explain why these enzymes have been independently recruited to perform peptide macrocyclization.

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