A short treatment of the NOD mouse model of type-1 diabetes with I-BET151, a small molecule bromodomain blocker, provides long-term protection from disease by inducing macrophages to adapt an anti-inflammatory tenor whilst promoting islet β cell regeneration.

A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.

Redox modification of STING represents a novel target for interferon regulation and control of herpesvirus replication.

We are writing to reply to the comment by Landegren et al., 2019 about our study (Meyer et al., 2016) on disease-ameliorating autoantibodies.

Cleavage of pannexin-1 channel by caspases facilitates the loss of intracellular ATP level and attenuates glycolytic metabolism of apoptotic cells.

Lymphocyte migration and autoimmunity induction rely on Formin-like 1-mediated actin network remodeling to push the lymphocyte nucleus through restrictive endothelial barriers.

Potential for specific microbiome-directed, MHC-restricted shaping of a commonly selected HIV-specific CD8+ T cell population was suggested by MHC class I yeast display-based peptide screening approaches.

Targeting the differentiation regulators and/or AMPs of keratinocytes, rather than targeting immune cells, may be an alternative approach for topical anti-psoriatic treatment, an area with high need for new drugs.