245 results found
    1. Developmental Biology

    Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

    Shreyasi Mukherjee et al.
    Genomic analysis of Xenopus gastrula reveal that the transcription factor Sox17 interacts with the Wnt signaling effector ß-catenin on enhancers to regulate the transcriptional program underlying endoderm germ layer formation.
    1. Immunology and Inflammation
    2. Neuroscience

    miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions

    Nicola S Orefice et al.
    A novel EAE model featuring cortical lesions and an autoimmune heterogeneity, two key parameters missing in the classical model, allows for insights in disease pathogenesis.
    1. Immunology and Inflammation

    Ageing compromises mouse thymus function and remodels epithelial cell differentiation

    Jeanette Baran-Gale et al.
    Thymus ageing is characterised by both compositional and transcriptional shifts amongst epithelial cells that perturb their differentiation, contribute to organ atrophy and ultimately impair immune function.
    1. Cancer Biology
    2. Immunology and Inflammation

    A perspective on HPK1 as a novel immuno-oncology drug target

    Sansana Sawasdikosol, Steven Burakoff
    HPK1 is an important immuno-oncology drug target that may induce superior anti-tumor immunity through the multiple roles HPK1 may play at multiple steps of the cancer immunity cycle.
    1. Medicine

    Metabolic response of blood vessels to TNFα

    Abidemi Junaid et al.
    The metabolic readout of endothelial function in the microvessels-on-a-chip facilitates mechanistic studies and detection of biomarkers for microvascular diseases in a physiological relevant environment.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reactive oxygen species oxidize STING and suppress interferon production

    Lili Tao et al.
    Redox modification of STING represents a novel target for interferon regulation and control of herpesvirus replication.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Co-expression analysis reveals interpretable gene modules controlled by trans-acting genetic variants

    Liis Kolberg et al.
    Co-expression analysis combined with functional enrichment improves the detection and prioritisation of trans-eQTLs when applied to emerging cell-type-specific datasets.
    1. Immunology and Inflammation

    Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

    Ricardo A Fernandes et al.
    Surrogate agonist peptide ligands discovered through screening of an IAb-peptide library potentiate expansion of visceral adipose tissue resident regulatory T cells and protect mice from inflammation and improve metabolic indices.
    1. Immunology and Inflammation

    Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis

    Heike Danzer et al.
    In the absence of human FcgRIIb function, an infection with Borrelia burgdorferi triggers enhanced autoreactive immune responses in humanized mice in vivo.
    1. Developmental Biology
    2. Immunology and Inflammation

    Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism

    Chew Leng Lim et al.
    Estrogen aggravates mammary involution through lysosome-mediated cell death, neutrophil recruitment via CXCR2 signalling, neutrophil-mediated inflammation and adipocyte repopulation.

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