A revised analytical framework grounded in the principle of binomial distribution captures the full clonality and dynamic shifts of hematopoiesis throughout ontogeny.
Eva M García-Cuesta, Pablo Martínez ... Mario Mellado
In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.
Activation of Activin A-expressing progenitor cells emerges as a pivotal mechanism in bone fracture healing, shedding light on a potential therapeutic avenue to augment bone repair processes.
Rémi Porte, Rita Silva-Gomes ... Alberto Mantovani
Long Pentaxin 3 is highly expressed by non-hematopoietic cells during Streptococcus pneumoniae invasive infections and regulates polymorphonuclear neutrophils' recruitment through interaction with P-selectin which damps inflammation-associated tissue damage and pneumococcal systemic dissemination.
Rafael Soares Godoy, Nicholas D Cober ... Duncan J Stewart
Single-cell transcriptomic analysis reveals novel regenerative endothelial cell populations that mediate remarkably rapid and complete microvascular repair in a novel model of acute lung injury induced by endothelial cell ablation.
Gerdien Mijnheer, Nila Hendrika Servaas ... Femke van Wijk
In localized autoimmune disease, there is autoantigen-driven expansion of both effector T cell and Treg clones that are highly persistent and are (re)circulating, and might represent interesting therapeutic targets.
