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    1. Cell Biology
    2. Neuroscience

    Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

    Rene Solano Fonseca, Patrick Metang ... Peter M Douglas
    Promoting a Warburg-like shift in astrocytic metabolism through reduced mitochondrial electron transport accommodates the energetic burden caused by brain trauma without overwhelming cellular respiration and redox to salvage dopaminergic neurons.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

    Eitan Lerner, Anders Barth ... Shimon Weiss
    A summary of the current “state-of-the-field” of single-molecule FRET used for probing biomolecular structural dynamics.
    1. Neuroscience

    Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome

    Han SJ Cheong, Katharina Eichler ... Gwyneth M Card
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Genetics and Genomics

    Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction

    Morgane Djebar, Isabelle Anselme ... Christine Vesque
    Brain ventricular astrogliosis and neuroinflammation precede scoliosis onset in the zebrafish rpgrip1l ciliary mutant and anti-inflammatory treatment drastically reduces scoliosis while correcting urotensin related peptide level is ineffective.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

    Amit Kumar, Oscar Vadas ... Stephen Matthews
    The glideosome-associated connector protein transitions between open and closed states, and this regulates its assembly and function during apicomplexan parasite motility.
    1. Cell Biology

    Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms

    Yeyun Ouyang, Mi-Young Jeong ... Jared Rutter
    SIT4 deletion and phosphate starvation increase mitochondrial membrane potential via electron transport chain dependent and independent manners, and the increased membrane potential induced by phosphate depletion is conserved between yeast, flies, and humans.
    1. Biochemistry and Chemical Biology

    On the role of nucleotides and lipids in the polymerization of the actin homolog MreB from a Gram-positive bacterium

    Wei Mao, Lars D Renner ... Rut Carballido-Lopez
    First 3D-structure and first observation of organized protofilaments of MreB from a Gram-positive bacterium, suggesting a model where ATP drives the formation of dynamic pairs of MreB protofilaments on a lipid surface.
    1. Developmental Biology
    2. Plant Biology

    A stochastic multicellular model identifies biological watermarks from disorders in self-organized patterns of phyllotaxis

    Yassin Refahi, Géraldine Brunoud ... Christophe Godin
    A stochastic model of phyllotaxis can explain the striking irregularities observed in the spiral patterns of plants and predicts that perturbation patterns provide key information about the underlying biochemical mechanisms.
    1. Neuroscience

    Neural substrates of cold nociception in Drosophila larva

    Atit A. Patel, Albert Cardona, Daniel N. Cox
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Microbiology and Infectious Disease

    Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga

    Yuu Ishii, Hironori Ishii ... Shinichiro Maruyama
    Coral symbiotic alga is capable of degrading the own cell wall components by cellulase-related enzymes and releasing sugars as a simple and autonomous environmental response, even when the host-derived signals are not present.