Browse the search results

A genome-wide screen identifies the BCAA catabolizing enzyme DBT as a master metabolic switch in the regulation of protein quality control when proteasomal activity is impaired.

Inhibiting KRAS^G12C and ULK-mediated autophagy is a novel treatment strategy to control the growth of KRAS^G12C-driven lung cancer in preclinical models of lung cancer.

Bacteria release ATP as part of their attack in sepsis.

Lysosomal clustering around the microtubule-organizing centre would be a promising therapeutic strategy for Parkinson's disease.

A novel targeted protein degradation system to achieve cell-type-specific enhancement of Wnt signaling.

A change in the electric charge of autophagosome membranes controls the recruitment of SNARE proteins to ensure that membrane fusion occurs at the right time during autophagy.

The autophagosomal membrane becomes negatively charged during maturation due to the accumulation of PI4P, leading to the recruitment of syntaxin 17, which is required for autophagosome-lysosome fusion.

Styxl2, a sarcomeric muscle-specific pseudophosphatase in vertebrates, functions in sarcomere assembly by promoting protein degradation of non-muscle myosin IIs.

MBOAT7 loss of function in hepatocytes contributes to ethanol-induced liver injury, offering crucial insights into the dysregulated lipid metabolism and impaired autophagy associated with advanced liver disease.

First systemic lysosomal proteomes in association with longevity and tissue specificity in C. elegans uncover lysosomal heterogeneity across multiple scales and provide valuable resources for understanding how lysosomes modulate signal transduction, organelle communication, tissue physiology, and organism longevity.