455 results found
    1. Cell Biology
    2. Neuroscience

    The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

    Aurelie de Rus Jacquet et al.
    Extracellular vesicles are proposed as novel, non-cell-autonomous mediators of neuronal atrophy in Parkinson's disease.
    1. Cancer Biology
    2. Cell Biology

    Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

    Brian Spurlock et al.
    A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.
    1. Cell Biology

    Protective mitochondrial fission induced by stress-responsive protein GJA1-20k

    Daisuke Shimura et al.
    Stress-induced alternative translation of an otherwise common gap junction protein generates an isoform that orchestrates protective mitochondrial fission and organ protection during anticipated ischemia.
    1. Cell Biology

    Endoplasmic reticulum tubules limit the size of misfolded protein condensates

    Smriti Parashar et al.
    The endoplasmic reticulum (ER) uses ER tubules and specific ER autophagy machinery to prevent toxic, dominant-interfering, disease-causing, mutant proteins from entering the secretory pathway.
    1. Cell Biology
    2. Physics of Living Systems

    Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics

    Mohammad Mofatteh et al.
    Latest advances in biological timing studies substantiate an emerging concept of autonomous clocks that are normally entrained by the cell cycle and/or the circadian clock to run in synchrony, but have evolved to run independently to regulate different cellular events.
    1. Neuroscience

    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

    Gustavo Della-Flora Nunes et al.
    mTORC1 and c-Jun are implicated in a possible mechanism causing myelin loss downstream of mitochondrial dysfunction in Schwann cells.
    1. Genetics and Genomics

    Human genetic analyses of organelles highlight the nucleus in age-related trait heritability

    Rahul Gupta et al.
    Although cellular organelles show a functional deterioration in aging, genetic loci associated with common age-associated disease instead nominate nuclear transcription factors across several age-related diseases.
    1. Biochemistry and Chemical Biology

    Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

    Urszula Nowicka et al.
    Defective mitochondrial protein import results in protein aggregation and a specific chaperone response in the cytosol, causatively linking mitochondrial function and cellular protein homeostasis disturbances observed in neurodegeneration.
    1. Genetics and Genomics
    2. Neuroscience

    A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

    Gha-Hyun J Kim et al.
    In vivo dopamine neuron imaging-based neuroprotective small molecule screen in larval zebrafish and mechanistic investigation using conditional CRISPR knockout and cell-type-specific RNA-seq analysis, coupled with cross-species analyses including human clinical data interrogation, uncover potential disease-modifying therapeutics for Parkinson's disease (PD).
    1. Cell Biology

    Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

    Lisa M Strong et al.
    The crystal structure of human WIPI2 bound to the ATG16L1 WIPI2-interacting region, combined with in vitro reconstitution and cellular autophagy assays, shows how the LC3 lipidation machinery is recruited in autophagy initiation.

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