Yeast cells adapt to harmful superoxide generated during mitochondrial oxidative phosphorylation by arresting respiration through mtDNA deletions whose emergence depend on superoxide dismutase 2 and the retrograde pathway.

Dcp2 C-terminal domain cis-regulatory elements collaborating with specific activators control decapping enzyme targeting and activation by orchestrating sequential assembly of distinct decapping complexes.

Transcription factors form clusters independently of the presence of DNA, which regulate target genes as opposed to individual monomers, addressing a longstanding question of how transcription factors can find gene targets so quickly.

Structure-function characterization of the EMC's cytoplasmic, transmembrane, and lumenal domains reveal features critical for terminal helix insertion and a specialized role for the lumenal domain in polytopic membrane protein biogenesis.

Prokaryotes use polycistronic messages for coordinated translation, whereas eukaryotic cells may achieve tunable protein synthesis by packaging monocistronic mRNAs into functional multiplexes via co-transcriptional interallelic coupling and non-canonical histone-H4 functions.

Analyses of the stalked budding bacterium Hyphomonas neptunium and its spiral-shaped relative Rhodospirillum rubrum reveal a conserved morphogenetic module that controls the establishment of complex bacterial cell shapes.

SIT4 deletion and phosphate starvation increase mitochondrial membrane potential via electron transport chain dependent and independent manners, and the increased membrane potential induced by phosphate depletion is conserved between yeast, flies, and humans.

Whereas partner-serving phenotype is intuitively quantified as benefit release rate, molecular genetics revealed an example where this thinking fails, motivating a more general metric.