A eukaryotic cell model overcomes metabolic deficiencies within a complex, self-establishing community that enables the growth-relevant exchange of metabolic intermediates.

De novo-generated small proteins can cause deattenuation of an amino acid biosynthetic operon by direct protein–RNA interactions.

Achieving autotrophy in E. coli by introducing a small number of genetic changes crosses a milestone in engineering major metabolic transitions and paves a way for sustainable bio-production from CO₂.

A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.

The lack of haem biosynthetic and degradative pathways in ticks offers new strategies to combat these parasites.

A switch-like cell fate divergence revealed by continuous single-cell tracking during entry into quiescence.

Effects of dietary lipids on organismal function and reproductive fitness are persistent and may depend on lipid identity, cause the evolution of lipid-based diet choice, alter food webs, change species responses to environmental change, and affect human nutrition.

Eukaryotic translation initiation factor 3 (eIF3) is required to stabilize the binding of mRNA at the exit channel of the small ribosomal subunit and acts at the entry channel to accelerate mRNA recruitment to the translation preinitiation complex.

The amination network for the distribution of assimilated ammonium throughout metabolism is defined by promiscuous transaminases, allowing a high flexibility of the network that supported engineering novel connections and even alternative ammonium assimilation entry points.

Genomic evidence suggests that L-gulonolactone oxidase-the terminal enzyme in vitamin C synthesis, which has been repeatedly lost throughout animal evolution-was lost in plants and other photosynthetic eukaryotes following plastid acquisition.