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    1. Medicine
    2. Neuroscience

    Sleep EEG in young people with 22q11.2 deletion syndrome: A cross-sectional study of slow-waves, spindles and correlations with memory and neurodevelopmental symptoms

    Nicholas A Donnelly, Ullrich Bartsch ... Matt W Jones
    Measures of sleep features such as spindles and slow waves differentiate between young people with 22q11.2 microdeletion syndrome and healthy controls, and may mediate the relationship between this genotype and psychiatric symptoms.
    1. Neuroscience

    Disrupting cortico-cerebellar communication impairs dexterity

    Jian-Zhong Guo, Britton A Sauerbrei ... Adam W Hantman
    The flow of neural activity across the cortico-cerebellar loop enables mice to reach for objects with skill and precision.
    1. Neuroscience

    Abstract rules drive adaptation in the subcortical sensory pathway

    Alejandro Tabas, Glad Mihai ... Katharina von Kriegstein
    Representations in the subcortical sensory pathway do not only adapt to stimulus properties but also rely on the observer’s subjective model of the world.
    1. Neuroscience

    Ripples reflect a spectrum of synchronous spiking activity in human anterior temporal lobe

    Ai Phuong S Tong, Alex P Vaz ... Kareem A Zaghloul
    A continuum of ripple oscillations in human anterior temporal lobe reflects the dynamic synchrony of populations of neurons during memory retrieval.
    1. Neuroscience

    Integration of overlapping sequences emerges with consolidation through medial prefrontal cortex neural ensembles and hippocampal–cortical connectivity

    Alexa Tompary, Lila Davachi
    Changes in cortical neural ensembles and heightened coupling between the hippocampus and cortex enable the eventual behavioral integration of memories with overlapping sequential information.
    1. Neuroscience

    Patterned perturbation of inhibition can reveal the dynamical structure of neural processing

    Sadra Sadeh, Claudia Clopath
    Neuronal networks with strong functional specificity of connections between excitatory and inhibitory neurons show specific dynamics of inhibitory stabilization, accompanied with rapid spontaneous activity transitions between highly selective functional states.
    1. Developmental Biology

    TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23)

    Louise A Stephen, Hasan Tawamie ... Hanno J Bolz
    Mutations in KIAA0586 (TALPID3) cause a severe ciliopathy called Joubert syndrome that affects organ, cell and centrosome polarity.
    1. Biochemistry and Chemical Biology

    Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

    Rajendra Uprety, Tao Che ... Susruta Majumdar
    The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.
    1. Neuroscience

    Complementary congruent and opposite neurons achieve concurrent multisensory integration and segregation

    Wen-Hao Zhang, He Wang ... Si Wu
    Opposite neurons in multisensory areas compute the cue disparity information essential for information segregation.
    1. Computational and Systems Biology

    Learning predictive cognitive maps with spiking neurons during behavior and replays

    Jacopo Bono, Sara Zannone ... Claudia Clopath
    Predictive cognitive maps can be learned during behavior and replays using in spiking neurons.