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    1. Neuroscience

    Texture coarseness responsive neurons and their mapping in layer 2–3 of the rat barrel cortex in vivo

    Liora Garion, Uri Dubin ... Jackie Schiller
    Neurons within rat somatosensory cortex are selective to texture and are spatially organized according to their texture preference.
    1. Neuroscience

    Mapping oxygen concentration in the awake mouse brain

    Declan G Lyons, Alexandre Parpaleix ... Serge Charpak
    Two-photon phosphorescence lifetime microscopy reveals the physiological values of oxygen concentration and blood flow parameters in the brains of awake mice.
    1. Developmental Biology
    2. Neuroscience

    A unique multi-synaptic mechanism involving acetylcholine and GABA regulates dopamine release in the nucleus accumbens through early adolescence in male rats

    Melody C Iacino, Taylor A Stowe ... Mark J Ferris
    A circuit within the nucleus accumbens that exists during a specific developmental window through early adolescence male rats may serve as a substrate that underlies heightened reward seeking in this population.
    1. Neuroscience

    AANAT1 functions in astrocytes to regulate sleep homeostasis

    Sejal Davla, Gregory Artiushin ... Donald J van Meyel
    Drosophila astrocytes regulate the homeostatic response to sleep need and express the AANAT1 enzyme that limits brain accumulation of serotonin and dopamine caused by overnight sleep deprivation.
    1. Neuroscience

    Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice

    Javad Karimi Abadchi, Zahra Rezaei ... Majid H Mohajerani
    Neocortical activity is drastically different around awake than sleep hippocampal ripples.
    1. Neuroscience

    Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

    Yael Mandelblat-Cerf, Rohan N Ramesh ... Mark L Andermann
    Gradual changes in the firing of specific hypothalamic neurons over many hours signal falling energy levels, while short-lived changes over seconds and minutes signal the availability of food.
    1. Neuroscience

    Synaptic mechanisms of top-down control in the non-lemniscal inferior colliculus

    Hannah M Oberle, Alexander N Ford ... Pierre F Apostolides
    Optogenetic and electrophysiological experiments show how a behaviorally relevant 'feedback' pathway from auditory cortex controls neural activity in the inferior colliculus, an auditory midbrain region important for processing complex time-varying sounds such as speech.
    1. Computational and Systems Biology
    2. Neuroscience

    Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants

    Laura Cornelissen, Seong-Eun Kim ... Charles B Berde
    Alpha EEG oscillations emerge at 4 months of age during sevoflurane general anesthesia, and unlike in adults, have a widespread spatial distribution that likely reflects differences in brain development.
    1. Neuroscience

    Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice

    Woohyun Kim, Jae Jin Shin ... Eunjoon Kim
    Social deficits in IRSp53/Baiap2-mutant mice accompany decreases in prefrontal neuronal firing variability, burst firing, and social information decoding accuracy, and memantine-dependent NMDAR inhibition, which rescues social deficits, alleviates burst firing, suggesting that burst firing links NMDAR dysfunction with social deficits.
    1. Neuroscience

    Thalamocortical synapses in the cat visual system in vivo are weak and unreliable

    Madineh Sedigh-Sarvestani, Larry A Palmer, Diego Contreras
    A characterization of LGN-V1 synaptic transmission properties demonstrates thalamocortical synapses in vivo are weak and unreliable, but biologically constrained models show they efficiently drive cortex.