8,429 results found
    1. Physics of Living Systems

    Geometric control of myosin II orientation during axis elongation

    Matthew F Lefebvre, Nikolas H Claussen ... Sebastian J Streichan
    During Drosophila axis elongation, the orientational pattern of the cytoskeleton is in good approximation stationary, while the genes thought to instruct these patterns are transported with the tissue flow.
    1. Developmental Biology

    The transcription factor Pitx2 positions the embryonic axis and regulates twinning

    Angela Torlopp, Mohsin A F Khan ... Claudio D Stern
    In higher vertebrates, the position of the embryonic axis (the location at which gastrulation starts) is determined by the transcription factor Pitx2, which suggests that the mechanisms of this process, and hence those that regulate twinning, are related to those that set up the left–right axis.
    1. Stem Cells and Regenerative Medicine

    Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis

    Dayan J Li, Conor L McMann, Peter W Reddien
    NR4A is a broadly conserved transcription factor that is required for concordance of patterning information and anatomy at both ends of the planarian anterior-posterior axis.
    1. Neuroscience

    Toward a more informative representation of the fetal–neonatal brain connectome using variational autoencoder

    Jung-Hoon Kim, Josepheen De Asis-Cruz ... Catherine Limperopoulos
    A nonlinear deep generative model can represent fetal–neonatal resting-state functional magnetic resonance imaging better than conventional linear models.
    1. Developmental Biology
    2. Genetics and Genomics

    Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver-Russell syndrome-like mouse models

    Suhee Chang, Diana Fulmer ... Marisa S Bartolomei
    Precise dosage of the imprinted H19 and Igf2 genes is critical for normal embryonic development, especially related to the cardiac-placental axis.
    1. Physics of Living Systems
    2. Cell Biology

    Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation

    Robert J Huebner, Abdul Naseer Malmi-Kakkada ... John B Wallingford
    Very local molecular patterns impart precise changes in the local mechanics of individual cell-cell junctions.
    1. Developmental Biology

    Hedgehog signaling patterns the oral-aboral axis of the mandibular arch

    Jingyue Xu, Han Liu ... Rulang Jiang
    SHH signaling acts through FOXF1/2 transcription factors and antagonizes BMP signaling to specify oral fate and pattern the oral-aboral axis of the mandibular arch to ensure proper formation of jaws.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Integrating analog and digital modes of gene expression at Arabidopsis FLC

    Rea L Antoniou-Kourounioti, Anis Meschichi ... Martin Howard
    The regulation of gene expression can be either binary (on/off digital regulation) or graded (analog regulation) and these fundamentally different regulatory modes can be integrated to control the expression of the same gene.
    1. Cell Biology

    PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

    Shuxian Li, Lingbing Li ... Xietong Wang
    Airborne PM2.5 exposure triggers oxidative stress and mitochondrial apoptosis in placental trophoblast cells via the KLF9/CYP1A1 transcriptional axis, ultimately leading to adverse pregnancy outcomes.
    1. Computational and Systems Biology
    2. Neuroscience

    Continuous lateral oscillations as a core mechanism for taxis in Drosophila larvae

    Antoine Wystrach, Konstantinos Lagogiannis, Barbara Webb
    Analysis of crawling Drosophila larva and agent based simulations suggest that an intrinsic rhythm rather than distinct actions underlie taxis behaviour, providing a core mechanism on which both sensory and memory pathways can converge.

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