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3,174 results found
    1. Genetics and Genomics
    2. Neuroscience

    The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing

    Shahar Alon et al.
    The first example of an animal where RNA-editing dramatically reshapes the entire proteome demonstrates that editing must be a critical evolutionary and adaptive force.
    1. Cell Biology
    2. Developmental Biology

    The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development

    Min Liu et al.
    The exon junction complex regulates the cell polarity determinant Discs large 1, which acts independently from its role in cell polarity to protect Dishevelled protein from lysosomal degradation in Wingless/Wnt signaling.
    1. Cell Biology
    2. Neuroscience

    Neurotrophins induce fission of mitochondria along embryonic sensory axons

    Lorena Armijo-Weingart et al.
    Induction of the fission of mitochondria-populating sensory axons is shown to be a novel biological action of neurotrophins.
    1. Neuroscience

    Noninvasive quantification of axon radii using diffusion MRI

    Jelle Veraart et al.
    Cell-specific architectural properties such as the axon diameter of the white matter of the human brain can be quantified accurately and non-invasively using diffusion magnetic resonance imaging.
    1. Cell Biology
    2. Neuroscience

    Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration

    Guiping Wang et al.
    Neurotrophin deprivation leads to rapid caspase-independent disassembly of the actin-spectrin-based membrane skeleton and spectrin-dependent retrograde signaling in axon degeneration.
    1. Structural Biology and Molecular Biophysics

    Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

    Wei Kan et al.
    In vitro and in cellulo characterization of oligomerization by the cytoplasmic Wnt effector dishevelled and its partner Axin provide new mechanistic principles for Wnt/β-catenin signaling.
    1. Developmental Biology
    2. Neuroscience

    NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord

    Janelle C Leggere et al.
    Alternative splicing of the Dcc gene, which is controlled by the NOVA RNA-binding proteins, is crucial during neuronal migration and axon guidance.
    1. Developmental Biology
    2. Neuroscience

    Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

    Timothy A Evans et al.
    The Roundabout2 receptor acts non-autonomously to promote commissural axons to cross the midline by antagonizing Slit-dependent axon repulsion.
    1. Neuroscience

    Inhibiting poly(ADP-ribosylation) improves axon regeneration

    Alexandra B Byrne et al.
    In C. elegans and mouse neurons, the balance between poly(ADP-ribose) glycohydrolases and poly(ADP-ribose) polymerases regulates axon regeneration downstream of DLK-1/MAPKKK signaling.
    1. Neuroscience

    mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

    Linqing Miao et al.
    The kinase AKT acts as a nodal point that coordinates both positive and negative cues to regulate the regeneration of central nervous system axons in adult mice.

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