1,074 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Theoretical relation between axon initial segment geometry and excitability

    Sarah Goethals, Romain Brette
    Theoretical analysis uncovers the impact of axon initial segment plasticity on neural excitability.
    1. Neuroscience

    Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling

    Naomi AK Hanemaaijer et al.
    High-speed calcium imaging from the axon initial segment shows that sodium channels are in part permeable to calcium ions.
    1. Neuroscience

    Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells

    Katalin Kerti-Szigeti, Zoltan Nusser
    All perisomatic GABAergic synpases on hippocampal pyramidal cells have a similar GABAA receptor subunit composition.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of diverse membrane target recognitions by ankyrins

    Chao Wang et al.
    The 24 ankyrin repeats of ankyrin proteins form an extended solenoid that provides an extremely conserved groove for binding to numerous targets via combinatorial usage of multiple weak interaction sites.
    1. Neuroscience

    Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron

    Elisa Galliano et al.
    In the mouse olfactory bulb, different types of local dopaminergic interneuron are produced before and after birth.
    1. Structural Biology and Molecular Biophysics

    Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions

    Keyu Chen et al.
    The 24 ANK repeats of each ankyrin are inhibited by combinatorial bindings of multiple disordered segments from their tail regions, suggesting a mechanism for differential regulations of membrane target bindings by ankyrins.
    1. Neuroscience

    β spectrin-dependent and domain specific mechanisms for Na+ channel clustering

    Cheng-Hsin Liu et al.
    β4 spectrin is required to maintain Na+ channels at the axon initial segment since, unlike nodes of Ranvier, β1 spectrin cannot substitute.
    1. Ecology
    2. Evolutionary Biology

    Point of View: Managing a sustainable deep-sea ‘blue economy’ requires knowledge of what actually lives there

    Adrian G Glover et al.
    High-throughput, integrative taxonomy has a crucial role to play in ensuring that the resources in our oceans are managed and developed in a sustainable manner.
    1. Evolutionary Biology

    Homo naledi and Pleistocene hominin evolution in subequatorial Africa

    Lee R Berger et al.
    A late Middle Pleistocene age for Homo naledi demonstrates a diversity of hominin species in Africa at this critical time in the archaeological record.
    1. Neuroscience

    Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion

    Steven Knafo et al.
    Bioluminescence monitoring and selective silencing in zebrafish larva reveal a novel sensorimotor circuit modulating speed in the moving spinal cord.

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