320 results found
    1. Developmental Biology

    The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle

    Husniye Kantarci et al.
    Glycolysis is locally enhanced and redirected in zebrafish to generate lactate, which functions as a signaling molecule to fully activate Fgf target genes required for proper sensory and neural development.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Chromatin accessibility dynamics and single cell RNA-Seq reveal new regulators of regeneration in neural progenitors

    Anneke Dixie Kakebeen et al.
    Regenerating neural progenitors of the Xenopus tropicalis tail prioritize differentiation to motor neuron types earlier than proliferation, a decision partly regulated by the transcription factors Pbx3 and Meis1.
    1. Developmental Biology
    2. Genetics and Genomics

    OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification

    Miruna Georgiana Ghinia Tegla et al.
    A retinal gene regulatory network prevents the formation of alternative cell fates from non-stochastic retinal progenitor cells.
    1. Physics of Living Systems

    Polar pattern formation induced by contact following locomotion in a multicellular system

    Masayuki Hayakawa et al.
    Transient cell-cell contact of eukaryotic cells, called contact following locomotion, causes cell density segregation, and its high-density region traveled as a band within the disordered background.
    1. Physics of Living Systems

    Mechanics and kinetics of dynamic instability

    Thomas CT Michaels et al.
    A theoretical framework for the growth of microtubules quantifies the roles of geometry, mechanics, kinetics and randomness and provides a phase diagram for dynamic instability in these self-assembled polymers.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth

    Baisakhi Mondal et al.
    Identification of the underlying molecular gene-regulatory mechanisms by which the histone deacetylase complex MiDAC controls neurite outgrowth.
    1. Cell Biology

    ERK3/MAPK6 controls IL-8 production and chemotaxis

    Katarzyna Bogucka et al.
    Understudied atypical MAPK, ERK3 controls epithelial secretome and chemotaxis.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Zygotic pioneer factor activity of Odd-paired/Zic is necessary for late function of the Drosophila segmentation network

    Isabella V Soluri et al.
    Mechanisms for shaping the chromatin accessibility landscape operate during development to regulate how embryonic patterning information is interpreted at the level of gene regulatory networks.
    1. Developmental Biology
    2. Genetics and Genomics

    Disparate expression specificities coded by a shared Hox-C enhancer

    Steve W Miller, James W Posakony
    Tucked within a well-known story of diverging gene function is a single enhancer encoding two inseparable specificities that regulates two adjacent genes, each with different spatiotemporal expression patterns.
    1. Developmental Biology
    2. Evolutionary Biology

    Developmental variability channels mouse molar evolution

    Luke Hayden et al.
    The nature and extent of developmental variation seen between mouse strains and genetically identical individuals explain why the first upper molar evolves along preferred path in murine rodents.

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