1,607 results found
    1. Neuroscience

    Balance between BDNF and Semaphorins gates the innervation of the mammary gland

    Hadas Sar Shalom et al.
    The innervation of the mammary gland is controlled by opposing effects of neurotrophic and repulsive factors and, once trophic signaling is inhibited the repulsive factors, may promote axonal pruning.
    1. Immunology and Inflammation
    2. Neuroscience

    Microglial trogocytosis and the complement system regulate axonal pruning in vivo

    Tony KY Lim, Edward S Ruthazer
    In vivo time lapse imaging reveals that microglial trogocytosis of presynaptic elements is regulated by the complement system which controls axon morphogenesis in the developing brain.
    1. Cell Biology
    2. Neuroscience

    Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance

    Kentarou Baba et al.
    Shootin1a, through its spatially regulated phosphorylation within growth cones, mediates the gradient reading and mechanoresponse for netrin-1-induced axon guidance.
    1. Neuroscience

    Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor signaling

    Marlen Zschätzsch et al.
    Asymmetric localization of the receptor EGFR within branches of axons is required to establish the precise wiring of neuronal networks within the Drosophila brain.
    1. Cell Biology
    2. Neuroscience

    Microtubules originate asymmetrically at the somatic golgi and are guided via Kinesin2 to maintain polarity within neurons

    Amrita Mukherjee et al.
    The somatic Golgi acts as an asymmetric MTOC within Drosophila neurons, and this, together with the action Kinesin-2, helps maintain minus-end-out microtubule polarity with proximal dendrites.
    1. Neuroscience

    A mathematical model explains saturating axon guidance responses to molecular gradients

    Huyen Nguyen et al.
    Mathematical modelling explains why molecular gradients sometimes cause axons to only turn weakly.
    1. Neuroscience

    Shank3 modulates sleep and expression of circadian transcription factors

    Ashley M Ingiosi et al.
    Shank3, a high confidence autism gene candidate, may be a key component of the mechanisms underlying sleep problems in autism.
    1. Neuroscience

    Node of Ranvier length as a potential regulator of myelinated axon conduction speed

    I Lorena Arancibia-Cárcamo et al.
    Node of Ranvier length is similar at successive nodes along single myelinated CNS axons, but differs between axons, and could potentially be tuned to adjust the conduction velocity of each axon.
    1. Cell Biology
    2. Developmental Biology

    Patronin governs minus-end-out orientation of dendritic microtubules to promote dendrite pruning in Drosophila

    Yan Wang et al.
    A minus-end-binding stabilizes minus-end-out microtubules in dendrites, which are required for dendrite-specific pruning during neuronal remodelling.
    1. Developmental Biology
    2. Physics of Living Systems

    Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain

    Amelia J Thompson et al.
    During embryonic development, tissue stiffness, which provides an important signal to motile cells, changes locally within tens of minutes in a well-controlled manner.

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