492 results found
    1. Developmental Biology
    2. Neuroscience

    Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase

    Lizhen Chen et al.
    Severing axons in C. elegans reveals a mechanism by which the axons sense acute damage and respond by sequential remodeling of their microtubule cytoskeleton.
    1. Developmental Biology
    2. Neuroscience

    Two receptor tyrosine phosphatases dictate the depth of axonal stabilizing layer in the visual system

    Satoko Hakeda-Suzuki et al.
    Two receptor tyrosine phosphatases having overlapping function for the determination of the final axon stabilizing layer is encoded for their cumulative cytoplasmic activity and ligand specificity in the visual system.
    1. Chromosomes and Gene Expression

    Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis

    David V Phizicky et al.
    Meiotic cells inhibit two distinct steps of replisome assembly with multiple kinases to prevent DNA replication between Meiosis I and Meiosis II.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz

    Ana Crespillo-Casado et al.
    The notion that the drug-like small molecule Sephin1 protects against protein misfolding by selectively disrupting a cellular phosphatase is refuted.
    1. Neuroscience

    Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries

    Sebastian Ocklenburg et al.
    Gene expression asymmetries in fetal spinal cord are triggered by epigenetic mechanisms suggesting that handedness has a spinal instead of a cortical origin.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop.

    Saravanapriah Nadarajan et al.
    PLK-1/2-mediated SYP-4 phosphorylation is dependent on crossover precursor formation, triggering a switch in the dynamic state of the synaptonemal complex that reduces the formation of further double-strand breaks at late meiotic prophase.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Extensive cargo identification reveals distinct biological roles of the 12 importin pathways

    Makoto Kimura et al.
    Transport-based high-throughput identification of cargo proteins specific to all 12 human importin-β family nuclear import receptors revealed biological processes that the cargo cohorts of each receptor are involved in.
    1. Genetics and Genomics

    Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling

    Andres M Lebensohn et al.
    A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.
    1. Cell Biology

    Selective sorting and destruction of mitochondrial membrane proteins in aged yeast

    Adam L Hughes et al.
    A new mitochondrial protein degradation pathway selectively sorts and destroys a subset of the mitochondrial membrane proteome to protect mitochondria in times of stress.
    1. Cell Biology

    Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network

    Songyu Wang et al.
    Experiments with mammalian cells and Xenopus egg extracts elucidate how three proteins cooperate to shape the reticular endoplasmic reticulum network.

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