Stride-related modulated firing by neurons of the cerebellar nuclei is required for smooth execution of practiced locomotion and persists more easily with synchronous than asynchronous Purkinje-mediated inhibition.
A compact neural network can form various associative memories that are encoded in a distributed manner, where each neuron stores different components of the memory.
Wilhelmina E van Riel, Ankit Rai ... Anna Akhmanova
Kinesin-4 KIF21B combines a processive motor activity with two non-motor microtubule-binding domains and an autoregulatory region to induce pausing of microtubule plus ends.
Rituja S Bisen, Fathima Mukthar Iqbal ... Jan M Ache
An in vivo electrophysiology approach identifies an incretin-like effect in Drosophila insulin-producing cells, highlighting key circuit dynamics which govern glucose homeostasis via conserved mechanisms.
A neural circuit between layer 2/3 pyramidal cells and somatostatin-expressing inhibitory neurons synchronizes spatially separated regions of the visual cortex to gamma rhythms.
Katharina Eichler, Stefanie Hampel ... Andrew M Seeds
A synaptic resolution somatotopic map of nearly all mechanosensory neurons on the Drosophila head that individually elicit aimed grooming of specific head locations and collectively elicit a head grooming sequence.
Lian Hollander-Cohen, Omer Cohen ... Berta Levavi-Sivan
Genetic loss-of-function approaches and functional calcium imaging reveal cholecystokinin as the primary regulator of follicle-stimulating hormone in zebrafish, redefining our understanding of gonadotropin regulation in vertebrates.
Sarah E Canetta, Emma S Holt ... Christoph Kellendonk
Prefrontal PV interneuron activity during development is necessary for prefrontal circuit maturation, supporting adult prefrontal network function and cognitive flexibility.