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The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain

An intracellular H9 motif facilitates the highly localised axonal surface expression of CB1R.

ZDHHC14 controls palmitoylation and axon initial segment targeting of PSD93 and Kv1-family potassium channels, events that are essential for normal neuronal excitability.

Targeting Abelson kinase can be beneficial for treating disorders characterized by dysregulated Down Syndrome Cell Adhesion Molecule signaling.

Direct observation in the developing fly brain indicates that the response of a growth cone in a gradient of a guidance cue is adhesion to the source of the cue rather than attraction by the gradient.

In C. elegans and mouse neurons, the balance between poly(ADP-ribose) glycohydrolases and poly(ADP-ribose) polymerases regulates axon regeneration downstream of DLK-1/MAPKKK signaling.

Two genetic mouse models for HCN1-linked developmental epileptic encephalopathy display distinct biophysical changes in HCN1 ion channel properties but similar worsening of seizures in response to antiepileptic drugs, thereby recapitulating key features of the human disease.

Long-term live imaging in intact developing Drosophila brains reveals a role for N-Cadherin-mediated fast filopodial dynamics and growth cone stabilization during neural circuit assembly.

A lineage-based intersectional genetic approach reveals brain-wide distribution and input connectivity of axo-axonic interneuron cells and establishes experimental access to study the circuit function of a ground truth cell type.

Myelin-associated inhibitors and chondroitin sulfate proteoglycans are not the primary mechanism stopping sensory axons regenerating into the spinal cord, although their removal can markedly enhance regeneration when combined with an intervention that elevates axon growth capacity sufficiently robustly.