1,447 results found
    1. Cell Biology
    2. Neuroscience

    The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction

    Ana Rita Costa et al.
    The axonal cytoskeletal contains an actomyosin-II network that controls circumferential axonal contraction and expansion with the potential of regulating fluctuations in diameter during action potential firing, trafficking, and degeneration.
    1. Neuroscience

    Local axonal morphology guides the topography of interneuron myelination in mouse and human neocortex

    Jeffrey Stedehouder et al.
    The joint combination of interbranch distance and local caliber is sufficient to predict with high accuracy the distribution of myelin internodes along individual axons of neocortical GABAergic interneurons.
    1. Neuroscience

    Noninvasive quantification of axon radii using diffusion MRI

    Jelle Veraart et al.
    Cell-specific architectural properties such as the axon diameter of the white matter of the human brain can be quantified accurately and non-invasively using diffusion magnetic resonance imaging.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Method for identification of condition-associated public antigen receptor sequences

    Mikhail V Pogorelyy et al.
    Without using control cohorts, a statistical method identifies candidates for immune receptors associated with diseases from repertoire sequencing datasets.
    1. Computational and Systems Biology
    2. Developmental Biology

    Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

    Sumeda Nandadasa et al.
    Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
    1. Developmental Biology

    Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

    Marketa Kaucka et al.
    The clonal oriented cell dynamics enables directional expansion and accurate scaling of sheet-like or rod-like cartilaginous elements and uncouples the mechanisms of elongation from thickness or diameter control.
    1. Neuroscience

    Sources of widefield fluorescence from the brain

    Jack Waters
    Widefield fluorescence from the brain arises from greater depth and area than typically appreciated and is usually a weighted average across cortical columns and often more than one cortical area.
    1. Neuroscience

    A platform for brain-wide imaging and reconstruction of individual neurons

    Michael N Economo et al.
    High-resolution fluorescence imaging of the complete mouse brain enables many neurons to be efficiently visualized in their entirety, revealing all targets of neurons that project widely across the brain.
    1. Developmental Biology
    2. Neuroscience

    Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance

    Hiroki Takechi et al.
    Timely regulation of growth cone dynamics, including filopodial and cytoskeletal rearrangements through phosphorylation signals from glial cells, shapes the photoreceptor axon targeting.
    1. Cell Biology
    2. Immunology and Inflammation

    Deep-learning-based three-dimensional label-free tracking and analysis of immunological synapses of CAR-T cells

    Moosung Lee et al.
    Rapid, label-free, volumetric, and automated assessment of the immunological synapse dynamics is demonstrated by combining optical diffraction tomography and deep-learning-based segmentation, providing a new option for immunological research.

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