184 results found
    1. Structural Biology and Molecular Biophysics

    NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

    Dalei Wu et al.
    Detailed structural analysis of NPAS1-ARNT and NPAS3-ARNT complexes, and further comparisons with other bHLH-PAS protein structures, show that this family of mammalian transcription factors have distinct ligand-binding pockets within their molecular architectures.
    1. Developmental Biology

    Regulation of the Drosophila ID protein Extra macrochaetae by proneural dimerization partners

    Ke Li, Nicholas E Baker
    Developmental genetic and cell culture studies indicate that the Inhibitor of DNA-binding protein Extra macrochaetae (Emc), previously thought to determine where bHLH proteins can act, is itself regulated by those bHLH dimerization partners at the level of protein stability.
    1. Developmental Biology

    BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity

    Richard H Row et al.
    Interplay between FGF-induced bHLH transcription factors and BMP-induced bHLH inhibitory id genes govern mesodermal cell fate choice along the mediolateral axis in both zebrafish and mouse.
    1. Developmental Biology
    2. Genetics and Genomics

    Nuclear receptor Ftz-f1 promotes follicle maturation and ovulation partly via bHLH/PAS transcription factor Sim

    Elizabeth M Knapp et al.
    Genetic analyses illustrate the novel requirement of Ftz-f1 and Sim in adult Drosophila ovaries for regulating follicle cell differentiation and ovulation that is likely conserved in mammals.
    1. Developmental Biology

    E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

    Gwenvael Le Dréau et al.
    Rather than acting as passive and neutral co-factors for proneural proteins, E proteins play an active role in modulating the way the distinct proneural proteins instruct neurogenesis.
    1. Evolutionary Biology
    2. Plant Biology

    Negative regulation of conserved RSL class I bHLH transcription factors evolved independently among land plants

    Suvi Honkanen et al.
    An ancient and conserved genetic mechanism for cell differentiation is under distinct negative regulation in different lineages of land plants.
    1. Plant Biology

    Brassinosteroids control root epidermal cell fate via direct regulation of a MYB-bHLH-WD40 complex by GSK3-like kinases

    Yinwei Cheng et al.
    Brassinosteroids signal through a pathway involving GSK3-like kinases and the WER-GL3/EGL3-TTG1 transcription factor complex to determine the fate of cells in the root epidermis.
    1. Plant Biology

    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module

    Juliana L Matos et al.
    An adult stem-cell lineage terminally differentiates via recruitment of the RETINOBLASTOMA-RELATED protein by a lineage specific transcription factor.
    1. Developmental Biology

    Repression by PRDM13 is critical for generating precision in neuronal identity

    Bishakha Mona et al.
    PRDM13, a transcriptional repressor, antagonizes activity of basic-helix-loop-helix transcriptional activators and protects the developing spinal cord from aberrant expression of ventral-restricted cell-type regulators to generate the correct composition of neurons in the dorsal spinal cord.
    1. Genetics and Genomics

    Insulin-like peptides and the mTOR-TFEB pathway protect Caenorhabditis elegans hermaphrodites from mating-induced death

    Cheng Shi et al.
    Hermaphroditic Caenorhabditis elegans slow the onset of mating-induced death through self-sperm-regulated insulin-like gene expression, which regulates the activity of the IIS/FOXO pathway, mTOR signaling, and the TFEB/HLH-30 transcription factor.

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