2,576 results found
    1. Genetics and Genomics

    Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways

    Shaohua Gu, Yuanzhe Shao ... Zhiyuan Li
    A novel bioinformatic pipeline predicts diverse pyoverdine structures and receptor groups with high accuracy, revealing significant hidden diversity in siderophores systems across Pseudomonas genomes.
    1. Ecology
    2. Microbiology and Infectious Disease

    Adaptability of non-genetic diversity in bacterial chemotaxis

    Nicholas W Frankel, William Pontius ... Thierry Emonet
    An experimentally constrained model shows that Escherichia coli faces fitness trade-offs in chemotaxis behaviors, and that adaptation of phenotypic diversity through altered gene regulation permits populations to resolve these trade-offs.
    1. Epidemiology and Global Health

    Improved characterisation of MRSA transmission using within-host bacterial sequence diversity

    Matthew D Hall, Matthew TG Holden ... Christophe Fraser
    Reconstruction of transmission pathways of methicillin-resistant Staphylococcus aureus using multiple genomes per host reveals great variation in the size of the transmission bottleneck and limited evidence for body site/phylogeny association.
    1. Ecology

    Engineering multifunctional rhizosphere probiotics using consortia of Bacillus amyloliquefaciens transposon insertion mutants

    Jingxuan Li, Chunlan Yang ... Zhong Wei
    Increasing the intra-species phenotypic diversity of a plant-beneficial bacterium effectively improves probiotic consortium functioning and plant growth promotion in agricultural systems.
    1. Computational and Systems Biology

    Phenotypic diversity and temporal variability in a bacterial signaling network revealed by single-cell FRET

    Johannes M Keegstra, Keita Kamino ... Thomas S Shimizu
    Noise in a signaling network comprising thousands of molecules shapes diversity across cell populations and generates giant temporal fluctuations at the single-cell level.
    1. Computational and Systems Biology

    Bactabolize is a tool for high-throughput generation of bacterial strain-specific metabolic models

    Ben Vezina, Stephen C Watts ... Kelly L Wyres
    Bactabolize is a pipeline for rapid and scalable production of accurate bacterial strain-specific metabolic models and growth phenotype predictions.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Machine learning-assisted discovery of growth decision elements by relating bacterial population dynamics to environmental diversity

    Honoka Aida, Takamasa Hashizume ... Bei-Wen Ying
    A smart combination of machine learning and high-throughput data generation of bacterial population dynamics successfully leads to an intriguing finding of the differentiation in decision-making components for bacterial growth.
    1. Ecology
    2. Microbiology and Infectious Disease

    Relationships between community composition, productivity and invasion resistance in semi-natural bacterial microcosms

    Matt Lloyd Jones, Damian William Rivett ... Thomas Bell
    Resident members of natural bacterial communities limit the growth of non-resident bacteria primarily by increasing overall community growth.
    1. Evolutionary Biology

    Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

    Claudia Igler, Jens Rolff, Roland Regoes
    The number and effects of mutations leading to full drug resistance crucially determine treatment failure probability and should be used to inform antimicrobial treatment strategies with regard to avoidance of resistance emergence.
    1. Ecology

    Latent functional diversity may accelerate microbial community responses to temperature fluctuations

    Thomas P Smith, Shorok Mombrikotb ... Thomas Bell
    A novel species-sorting experiment finds that phylogenetically and functionally distinct microbial communities emerge under different temperature conditions due to the resuscitation of latent diversity.

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