1,404 results found
    1. Ecology
    2. Evolutionary Biology

    CRISPR-based herd immunity can limit phage epidemics in bacterial populations

    Pavel Payne, Lukas Geyrhofer ... Jonathan P Bollback
    Bacteria can exhibit herd immunity protection against phages, which may play a significant role in their ecology and evolution.
    1. Ecology
    2. Microbiology and Infectious Disease

    Relationships between community composition, productivity and invasion resistance in semi-natural bacterial microcosms

    Matt Lloyd Jones, Damian William Rivett ... Thomas Bell
    Resident members of natural bacterial communities limit the growth of non-resident bacteria primarily by increasing overall community growth.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub

    Martin Wilkinson, Oliver J Wilkinson ... Mark S Dillingham
    New cryoEM structures reveal how small bacteriophage proteins suppress bacterial immunity.
    1. Cell Biology

    CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens

    Jin Wang, Jiayi Xie ... Meng Zhao
    scRNA-seq identified CXCR4high MKs can funtionally regulate host-defense immune response against bacterial infection.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans

    Gurmeet Kaur, Lakshminarayan M Iyer ... L Aravind
    Prokaryotic TRADD-N and Death-like adaptor domains in diverse predicted apoptosis and immune systems from multicellular prokaryotes and metazoans indicate the common origin of key apoptosis mechanisms required for the stabilization of multicellularity.
    1. Plant Biology

    Host-induced bacterial cell wall decomposition mediates pattern-triggered immunity in Arabidopsis

    Xiaokun Liu, Heini M Grabherr ... Andrea A Gust
    Arabidopsis lysozyme LYS1 generates soluble peptidoglycan fragments to mediate pattern-triggered immunity.
    1. Ecology

    Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly

    Inés Martínez, Maria X Maldonado-Gomez ... Jens Walter
    Experiments in ex-germ-free mice establish a measurable effect of colonization history on gut microbiota assembly, illuminating a potential cause for the high levels of unexplained individuality in host-associated microbial communities.
    1. Microbiology and Infectious Disease

    Co-evolution within structured bacterial communities results in multiple expansion of CRISPR loci and enhanced immunity

    Nora C Pyenson, Luciano A Marraffini
    Cells must acquire multiple viral spacer sequences to neutralize mutant escaper phages and form colonies during the CRISPR-Cas immune response.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A novel role for lipid droplets in the organismal antibacterial response

    Preetha Anand, Silvia Cermelli ... Steven P Gross
    Histones bound to lipid droplets inside cells offer protection against bacteria in flies, and possibly mice, thus suggesting a possible new innate immunity pathway.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Nitrogenase resurrection and the evolution of a singular enzymatic mechanism

    Amanda K Garcia, Derek F Harris ... Betül Kaçar
    Life is constrained in its sampling of protein sequence space to catalyze one of the most energetically challenging biochemical reactions.

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