10 results found
    1. Developmental Biology

    Drosophila neprilysins control insulin signaling and food intake via cleavage of regulatory peptides

    Benjamin Hallier et al.
    The catalytic activity of a Drosophila neprilysin is critical to proper insulin expression and food intake by regulating homeostasis of distinct signaling peptides.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Protein gradients on the nucleoid position the carbon-fixing organelles of cyanobacteria

    Joshua S MacCready et al.
    Carboxysomes, the carbon-fixation machinery of cyanobacteria, are equidistantly-positioned by dynamic gradients of the protein McdA on the nucleoid that emerge through interaction with a previously unidentified carboxysome factor, McdB.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Evidence for a DNA-relay mechanism in ParABS-mediated chromosome segregation

    Hoong Chuin Lim et al.
    In vitro, in vivo and in silico evidence suggests that bacteria exploit intrinsic chromosomal fluctuations to achieve intracellular transport.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism

    Robert J Nichols et al.
    A protein-bounded organelle-like compartment from Synechococcus elongatus PCC 7942 is upregulated under sulfur starvation and contains a cysteine desulfurase cargo enzyme.
    1. Physics of Living Systems

    Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila

    Myron Barber Child VI et al.
    Biophysical modeling and quantitative live-cell imaging converge to show that the century-old puzzle of somatic homolog pairing in Drosophila operates via a button model.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Effects of microcompartmentation on flux distribution and metabolic pools in Chlamydomonas reinhardtii chloroplasts

    Anika Küken et al.
    Mathematical models reveal that under the physiologically different conditions ambient and high CO2, two algal microcompartments are metabolically connected by facilitated transport.
    1. Genetics and Genomics

    Differing isoforms of the cobalamin binding photoreceptor AerR oppositely regulate photosystem expression

    Haruki Yamamoto et al.
    A novel B12 containing photoreceptor is synthesized as two different isoforms that interact with the same transcription factor, with one isoform directing activation and the other promoting repression of photosystem synthesis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation

    Ivana Petrovska et al.
    A starvation-induced drop in cytosolic pH promotes assembly of budding yeast glutamine synthetase into enzymatically inactive filaments that function as enzyme storage depots.
    1. Cell Biology

    Reconstitution of self-organizing protein gradients as spatial cues in cell-free systems

    Katja Zieske, Petra Schwille
    A minimal cell-like system with defined geometry has been used to investigate the establishment and spatial control of a protein gradient that positions the bacterial cell division machinery.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Many-molecule encapsulation by an icosahedral shell

    Jason D Perlmutter et al.
    Computational and theoretical models reveal mechanisms by which protein compartments assemble around enzymes and reagents to facilitate reactions in bacteria, allowing the identification of strategies for reengineering such compartments as customizable nanoreactors.

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