455 results found
    1. Physics of Living Systems

    Mechanical instability and interfacial energy drive biofilm morphogenesis

    Jing Yan et al.
    Mechanical instabilities are shown to underlie the development of bacterial biofilm morphology, suggesting an ancient origin for mechano-morphogenesis, which is known to drive developmental processes in tissues in higher organisms.
    1. Physics of Living Systems
    2. Developmental Biology

    Unified quantitative characterization of epithelial tissue development

    Boris Guirao et al.
    A new approach measures the respective participations of elementary cell behaviors – such as cell division, intercalation, shape change and death – in the shaping of animal tissues.
    1. Physics of Living Systems

    Controlling contractile instabilities in the actomyosin cortex

    Masatoshi Nishikawa et al.
    Combining quantitative biological experiment and physical description of actomyosin cortex reveals a contractile instability in the cortex of C. elegans embryo, and its biochemical control in order to robustly drive morphogenetic events.
    1. Computational and Systems Biology
    2. Developmental Biology

    Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

    Sumeda Nandadasa et al.
    Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
    1. Cell Biology
    2. Physics of Living Systems

    Morphogenetic degeneracies in the actomyosin cortex

    Sundar Ram Naganathan et al.
    Distinct molecular functions contribute to the same material property at larger scales leading to degenerate functionality.
    1. Stem Cells and Regenerative Medicine

    Embryonic origin of adult stem cells required for tissue homeostasis and regeneration

    Erin L Davies et al.
    Anarchic, cycling piwi-1+ embryonic cells gives rise to neoblasts, pluripotent stemcells required for development of all organ systems during S. mediterranea embryogenesis, as well as the maintenance andregeneration of tissues during adulthood.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A model symbiosis reveals a role for sheathed-flagellum rotation in the release of immunogenic lipopolysaccharide

    Caitlin A Brennan et al.
    Both beneficial and pathogenic bacteria can use their sheathed flagella during host colonization as a novel toxin-/signal-delivery mechanism.
    1. Cell Biology
    2. Developmental Biology

    Ingression-type cell migration drives vegetal endoderm internalisation in the Xenopus gastrula

    Jason WH Wen, Rudolf Winklbauer
    The cellular behaviours that underlie the internalization of the multilayered endoderm anlage in Xenopus laevis link the ancestral mode of vertebrate gastrulation to common, epithelial-based mechanisms of gastrulation in non-vertebrate animals.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Elastic instability during branchial ectoderm development causes folding of the Chlamydosaurus erectile frill

    Sophie A Montandon et al.
    Robust wrinkling pattern of the frilled dragon’s spectacular erectile ruff emerges from an elastic instability during homogeneous growth of the embryonic neck fold frustrated by its attachment to adjacent tissues.
    1. Cell Biology
    2. Genetics and Genomics

    NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling

    Malini Rajan et al.
    Nuclear receptor NHR-14 regulates the subcellular localization of the zinc transcription factor PQM-1 to coordinate innate immunity with iron sequestration during pathogen infection in C. elegans..

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