Allison Hillary Williams, Richard Wheeler ... Ivo Gomperts Boneca
Lytic transglycosylase enhances the activity of its protein partner, and its catalytic domain can be targeted to disrupt cell-wall integrity, protein partner function, and bacterial survival (Neisseria meningitidis) in hosts.
A broadly useful phenotypic profiling dataset was generated and used to identify a cofactor required for a polar cell wall synthase in Corynebacterium glutamicum that is conserved throughout the Actinobacteria.
The Pkpk and Pksple isoforms of the Prickle protein determine right- or left-handed bristle morphogenesis by coupling Frizzled/Vang signaling to the Fat/Dachsous PCP directional signal in opposite directions.
Michael W Susman, Edith P Karuna ... Hsin-Yi Henry Ho
Kif26b, a new component of the evolutionarily conserved Wnt5a-Ror signaling pathway, is controlled by regulated proteolysis and plays crucial roles in mediating vertebrate embryonic tissue morphogenesis.
Phylogenetic analyses of the four core virion proteins support a new evolutionary model for the origin of the main groups of eukaryotic viruses in the kingdom Bamfordvirae.
Jeanyoung Jo, Krista L Cortez ... Lars EP Dietrich
During growth in biofilms and host infection, the opportunistic pathogen Pseudomonas aeruginosa employs respiratory heterocomplexes that support extracellular electron shuttling and pathogenicity.
Gizem Özbaykal, Eva Wollrab ... Sven van Teeffelen
For initiation of cell-wall insertion, the cross-linking enzyme PBP2 stably binds to a component of the cell envelope that is different from MreB filaments.
Arul Subramanian, Lauren Fallon Kanzaki ... Thomas Friedrich Schilling
Perturbation of mechanical force at muscle attachments and its effects on tendon morphogenesis provides insights into the mechanisms underlying cellular responses to tensional force and resulting extracellular matrix production.