Regnase-1, an RNase suppressing proinflammatory mRNAs, interacts with 14-3-3, which diminishes cytokine mRNA recognition and the nuclear-cytoplasmic shuttling of Regnase-1 under inflammatory conditions.
Malaria parasites have simplified and adapted their mitochondrial metabolism to lack fatty acid synthesis but retain an unusual acyl carrier protein required for stability of the core iron-sulfur cluster biogenesis complex.
A previously uncharacterized type of bivalent chromatin plays an important role controlling the timely induction of genes involved in making a potent defense metabolite upon a pathogen signal in Arabidopsis.
Alternative splicing and the endoplasmic reticulum (ER)-associated protein degradation (ERAD) system represent essential, fat depot-specific components of the adipogenesis that are altered in preadipocytes from obese individuals with metabolic disease.
A proteomics-based approach identifies novel substrate proteins of the Lon protease in Caulobacter crescentus and reveals a critical role of Lon in regulating flagella assembly and stalk biogenesis during the cell cycle.